AI Article Synopsis
- The study investigates the sub-lethal toxicity of perfluoroheptanoic acid (PFHpA) on developing zebrafish to understand its potential effects on aquatic life.
- Findings showed that while PFHpA was not acutely toxic at concentrations up to 50 µM, it did affect cellular respiration and gene expression related to mitochondrial function at higher doses.
- Additionally, locomotor activity in zebrafish decreased with low-level PFHpA exposure, but no anxiety-related behaviors were observed, providing insights for environmental risk assessments of PFAS chemicals.
Article Abstract
The potential toxicity of several perfluoroalkyl and polyfluoroalkyl substances (PFASs) to aquatic species are not well understood. Here, we assessed the sub-lethal toxicity potential of perfluoroheptanoic acid (PFHpA) to developing zebrafish. PFHpA was not acutely toxic to fish up to 50 µM and there was > 96% survival in all treatments. Exposure to 200 µM PFHpA decreased ATP-linked respiration of embryos. There was no evidence for ROS induction in 7-day-old larvae fish exposed to 0.1 µM or 1 µM PFHpA. Twenty-four transcripts related to mitochondrial complexes I through V were measured and atp06, cox4i1, and cyc1 levels were decreased in larval zebrafish in a concentration-dependent manner by PFHpA exposure. Locomotor activity was reduced in fish exposed to 0.1 µM PFHpA based on a visual motor response test. Anxiolytic-type behaviors were not affected by PFHpA. This study contributes to environmental risk assessments for perfluorinated chemicals.
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| http://dx.doi.org/10.1016/j.etap.2022.104037 | DOI Listing |
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