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Effects of a New Enzymatic Debrider (SN514-066b) on Eschar Protein Digestion, Burn Wound Debridement, and Healthy Skin Irritation.
Adv Wound Care (New Rochelle)
January 2025
Kenatha Scientific Consulting LLC, Fort Worth, Texas, USA.
SN514 is a thermolysin-like enzyme under development as a debrider. Preclinical and non-clinical studies supported a first in human healthy volunteer study to predict the need for protection of periwound skin. Pharmacologic activity testing compared digestion of collagen, fibrin, and elastin with relevant enzymes.
View Article and Find Full Text PDFNon-Thrombotic Filling Defects in Cerebral Veins and Sinuses: When Normal Structures Mimic a Disease.
Neurol Int
January 2025
Neuroradiology Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Viale Risorgimento 80, 42123 Reggio Emilia, Italy.
Cerebral venous thrombosis (CVT) is a rare and potentially critical cerebrovascular disease involving intracranial dural sinuses and veins. The diagnosis is a stepwise pathway starting from clinical suspicion and employing several neuroradiological techniques, mainly Computed Tomography (CT)-based and Magnetic Resonance Imaging (MRI)-based modalities. The neuroradiological findings, both in the diagnostic phase and in the follow-up phase, may provide some results at risk for misdiagnosis.
View Article and Find Full Text PDFSpeciation of Potentially Carcinogenic Trace Nickel(II) Ion Levels in Human Saliva: A Sequential Metabolomics-Facilitated High-Field H NMR Investigation.
Metabolites
December 2024
Leicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK.
Since the biological activities and toxicities of 'foreign' and/or excess levels of metal ions are predominantly determined by their precise molecular nature, here we have employed high-resolution H NMR analysis to explore the 'speciation' of paramagnetic Ni(II) ions in human saliva, a potentially rich source of biomolecular Ni(II)-complexants/chelators. These studies are of relevance to the corrosion of nickel-containing metal alloy dental prostheses (NiC-MADPs) in addition to the dietary or adverse toxicological intake of Ni(II) ions by humans. Unstimulated whole-mouth human saliva samples were obtained from n = 12 pre-fasted (≥8 h) healthy participants, and clear whole-mouth salivary supernatants (WMSSs) were obtained from these via centrifugation.
View Article and Find Full Text PDFHepatic Biomarker Abnormalities in the Cardiac Intensive Care Unit: Proposed Criteria for Cardiohepatic Syndrome.
JACC Adv
January 2025
Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Background: Liver synthetic dysfunction predicts outcomes in cardiac intensive care unit (CICU) patients.
Objectives: The purpose of this study was to evaluate the associations between the severity and extent of admission liver function test (LFT) abnormalities and mortality in a mixed CICU population.
Methods: This historical cohort study included unique CICU patients from 2007 to 2018 with available data for admission LFT values.
Lactational performance effects of 3-nitrooxypropanol supplementation to dairy cows: A meta-regression.
J Dairy Sci
February 2025
Department of Animal Science, The Pennsylvania State University, University Park, PA 16802. Electronic address:
A meta-regression was conducted to determine the production effects of 3-nitrooxypropanol (3-NOP) and investigate their associations with dose, dietary nutrient composition, and supplementation length in dairy cows. Forty treatment and control mean comparisons extracted from 21 studies conducted or published between 2014 to 2024 were used in the meta-regression. Response variables were DMI, milk yield (MY), ECM yield, ECM feed efficiency, BW, BW change, and concentrations of milk fat, true protein, lactose, and MUN.
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