AI Article Synopsis
- RSV is a significant cause of acute lower respiratory infections in infants, and its infection rates remained unchanged even during the COVID-19 pandemic.
- A study conducted between July 2021 and January 2022 found that 21.79% of nasopharyngeal swabs from outpatients tested positive for RSV, with the highest susceptibility in children aged 3-6 years.
- Phylogenetic analysis revealed that the dominant strain of RSV in Hangzhou during this period was the ON1 subtype for RSV-A and BA9 for RSV-B, with ten notable mutations identified that could impact its biological behavior.
Article Abstract
Background: Respiratory syncytial virus (RSV) is one of the main pathogens that causes acute lower respiratory tract infection (ARTI) in infants. During the Coronavirus Disease 2019 (COVID-19) pandemic, although strict interventions have been implemented, RSV infection has not decreased.
Objectives: To study the epidemiological and genetic characteristics of RSV circulating in Hangzhou after the peak of COVID-19.
Methods: A total of 1225 nasopharyngeal swabs were collected from outpatients with ARTIs from July 2021 to January 2022 in The Children's Hospital, Zhejiang University School of Medicine.
Results: A total of 267 (21.79%) of the 1225 samples were RSV positive. There was no gender bias. However, an obvious age preference for infection was observed, and children aged 3-6 years were more susceptible, which was very different from previous RSV pandemic seasons. Phylogenetic analysis of 115 sequenced RSV isolates showed that all the RSV-A viruses belong to the ON1 subtype, which could be clustered into three clusters. While all the RSV-B viruses belong to BA9. Further analysis of the mutations highlights the fixation of ten mutations, which should be given extra attention regarding their biological properties.
Conclusion: The incidence of RSV infection in preschool children reported in this study is high. Phylogenetic analysis showed that the subtype A ON1 genotype was the dominant strain in Hangzhou from July 2021 to January 2022.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9747354 | PMC |
| http://dx.doi.org/10.1016/j.jcv.2022.105354 | DOI Listing |
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