AI Article Synopsis
Article Abstract
Four novel Salan Hf complexes stabilized by 2,6-dipicolinic acid (Dipic) were synthesized and characterized by H, C NMR and X-ray diffraction spectroscopy. These Hfbis-chelates could be obtained in good to excellent yields (88%-91%) and demonstrated rather good stability in aqueous media and on silica gel. [LHfDipic] containing steric bulk L were stable in about 10% HO (HO/THF (v/v)), however, [LHfDipic] with non-steric L could slowly dissociate and release nontoxic L. [LHfDipic] showed excellent anti-tumoral activity in the range of cisplatin (Hela S3: IC = 3.5 ± 0.4 μM, Hep G2: IC = 11.2 ± 2.1 μM). In addition, the cellular uptake and apoptosis investigation of [LHfDipic] suggested a fast cellular uptake process against Hela S3 cells with an almost exclusive induced apoptosis cell death path.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jinorgbio.2022.112094 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Dynamic molecular architecture of the synaptonemal complex.
Sci Adv
January 2025
Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720-3200, USA.
During meiosis, pairing between homologous chromosomes is stabilized by the assembly of the synaptonemal complex (SC). The SC ensures the formation of crossovers between homologous chromosomes and regulates their distribution. However, how the SC regulates crossover formation remains elusive.
View Article and Find Full Text PDFExploring Singlet Carbyne Anions and Related Low-Valent Carbon Species Utilizing a Cyclic Phosphino Substituent.
Acc Chem Res
January 2025
Department of Chemistry and Research Center for Chemical Biology and Omics Analysis, College of Science, Southern University of Science and Technology, Shenzhen 518055, China.
ConspectusThe advancement of synthetic methodologies is fundamentally driven by a deeper understanding of the structure-reactivity relationships of reactive key intermediates. Carbyne anions are compounds featuring a monovalent anionic carbon possessing four nonbonding valence electrons, which were historically confined to theoretical constructs or observed solely within the environment of gas-phase studies. These species possess potential for applications across diverse domains of synthetic chemistry and ancillary fields.
View Article and Find Full Text PDFBoosting the catalytic efficiency of UGT51 for efficient production of rare ginsenoside Rh2.
Folia Microbiol (Praha)
January 2025
Biofuels Institute, School of Emergency Management, School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang, 212013, China.
Ginsenoside Rh2(S) is well-known for its therapeutic potential against diverse conditions, including some cancers, inflammation, and diabetes. The enzymatic activity of uridine diphosphate glycosyltransferase 51 (UGT51) from Saccharomyces cerevisiae plays a pivotal role in the glycosylation process between UDP-glucose (donor) and protopanaxadiol (acceptor), to form ginsenoside Rh2. However, the catalytic efficiency of the UGT51 has remained a challenging task.
View Article and Find Full Text PDFEvaluation of methoxyflavones as dengue NS2B-NS3 protease inhibitors: an in silico and in vitro studies.
Mol Divers
January 2025
Department of Biosciences, Faculty of Science, Universiti Teknologi Malaysia, 81310, Johor Bahru, Johor, Malaysia.
Dengue is one of the most prevalent viruses transmitted by the Aedes aegypti mosquitoes. Currently, no specific medication is available to treat dengue diseases. The NS2B-NS3 protease is vital during post-translational processing, which is a key target in this study.
View Article and Find Full Text PDFAdvances in accessing rare oxidation states of nickel for catalytic innovation.
Chem Commun (Camb)
January 2025
Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, 721302, India.
Nickel catalysis has experienced a renaissance over the past two decades, driven by its ability to access diverse oxidation states (0 to +4) and unique reactivity. This review consolidates the advancements in nickel chemistry, providing an overview of ligands that stabilize specific nickel oxidation states. The stability, reactivity, and catalytic applications of Ni sources, including generation from air- and moisture-stable Ni precursors, are discussed, along with the roles of Ni and Ni intermediates in catalytic cycles.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!