AI Article Synopsis
- The non-ciliated bronchiolar cell (NCBC) in the lungs defends against harmful substances and increases mucin and CC16 protein production in response to exposure to toxins.
- A study explored how male and female CD-1 mice reacted differently to inhaling vanadium (V) over four weeks, finding that both sexes experienced hyperplasia and NCBC sloughing but had varying levels of mucosecretory metaplasia.
- Results showed increased expression of CC16 in both genders, but male mice exhibited more severe changes, indicating significant differences in susceptibility to toxic inhalants based on sex.
Article Abstract
The non-ciliated bronchiolar cell (NCBC) is responsible for the defense of the lung and responds to negative stimuli such as exposure to toxic pro-oxidant substances, which triggers the hyperproduction and hypersecretion of mucins and CC16 protein. The literature demonstrates that physiological and pathological responses in the lung can be influenced by the organism's sex. The objective of this report was to evaluate response differences to vanadium (V) inhalation in male and female CD-1 mice. Mice were exposed to V for four weeks. Hyperplasia of bronchiolar epithelium, small inflammatory foci and sloughing of the NCBC were observed, without changes between sexes and throughout the exposure time. Mucosecretory metaplasia was found in both males and females, however it was more drastic in males. The expression of CC16 increased in both sexes. This study demonstrated a different susceptibility between male and female mice exposed to V inhalation regarding mucosecretory metaplasia.
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| http://dx.doi.org/10.14670/HH-18-566 | DOI Listing |
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