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http://dx.doi.org/10.3389/fphys.2022.1092304 | DOI Listing |
Front Physiol
December 2023
Institute of Neuro- and Sensory Physiology, Georg-August-University, Göttingen, Germany.
A concept of Ca nanodomains established in the cytoplasm after opening single-calcium channels helps mechanistically understand the physiological mechanisms of Ca signaling. It predicts standing gradients of cytoplasmic free Ca around single channels in the plasma membrane. The fate of bound Ca attracted much less attention.
View Article and Find Full Text PDFFront Immunol
December 2023
Laboratory of Immunopharmacology, Department of Genetics, Oswaldo Cruz Institute, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Lipids perform a series of cellular functions, establishing cell and organelles' boundaries, organizing signaling platforms, and creating compartments where specific reactions occur. Moreover, lipids store energy and act as secondary messengers whose distribution is tightly regulated. Disruption of lipid metabolism is associated with many diseases, including those caused by viruses.
View Article and Find Full Text PDFFront Physiol
November 2022
School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, United Kingdom.
J Membr Biol
October 2022
Center for Membrane and Cell Physiology, University of Virginia, Charlottesville, VA, USA.
Caveolins are an unusual family of membrane proteins whose primary biological function is to build small invaginated membrane structures at the surface of cells known as caveolae. Caveolins and caveolae regulate numerous signaling pathways, lipid homeostasis, intracellular transport, cell adhesion, and cell migration. They also serve as sensors and protect the plasma membrane from mechanical stress.
View Article and Find Full Text PDFCells
October 2020
Institute of Biological Chemistry, Biophysics and Bioengineering, School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh Campus, Edinburgh EH14 4AS, UK.
The cyclic nucleotides 3',5'-adenosine monophosphate (cyclic AMP) signalling system underlies the control of many biological events and disease processes in man. Cyclic AMP is synthesised by adenylate cyclase (AC) enzymes in order to activate effector proteins and it is then degraded by phosphodiesterase (PDE) enzymes. Research in recent years has identified a range of cell-type-specific cyclic AMP effector proteins, including protein kinase A (PKA), exchange factor directly activated by cyclic AMP (EPAC), cyclic AMP responsive ion channels (CICs), and the Popeye domain containing (POPDC) proteins, which participate in different signalling mechanisms.
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