AI Article Synopsis
- The olfactory centres are the oldest parts of the brain and are linked to various neurological issues, including those caused by COVID-19, which has raised interest in human smell functionality.
- Despite this interest, there's a lack of recent data on how human olfactory centres develop and their normal structure, leading to inconsistencies in research terminology.
- The review aims to clarify and discuss the developmental timeline and structure of human olfactory centres to improve understanding and future research efforts.
Article Abstract
The olfactory centres are the evolutionary oldest and most conservative area of the telencephalon. Olfactory deficiencies are involved in a large spectrum of neurologic disorders and neurodegenerative diseases. The growing interest in human olfaction has been also been driven by COVID-19-induced transitional anosmia. Nevertheless, recent data on the human olfactory centres concerning normal histology and morphogenesis are rare. Published data in the field are mainly restricted to classic studies with non-uniform nomenclature and varied definitions of certain olfactory areas. While the olfactory system in model animals (rats, mice, and more rarely non-human primates) has been extensively investigated, the developmental timetable of olfactory centres in both human prenatal and postnatal ontogeny are poorly understood and unsystemised, which complicates the process of analysing human material, including medical researches. The main purpose of this review is to provide and discuss relevant morphological data on the normal ontogeny of the human olfactory centres, with a focus on the timetable of maturation and developmental cytoarchitecture, and with special reference to the definitions and terminology of certain olfactory areas.
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| http://dx.doi.org/10.1016/j.neures.2022.12.005 | DOI Listing |
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