AI Article Synopsis
- - This study examines how liver fibrosis impacts bone health in obese people with non-alcoholic fatty liver disease (NAFLD), revealing a significant connection between increased liver fibrosis and lower bone mineral density (BMD) and microstructure.
- - In a sample of 1,872 obese individuals, those with conditions like osteopenia or osteoporosis had notably higher levels of liver fibrosis (FIB-4 scores), with these scores correlating negatively with factors like osteocalcin and IGF-1, which are important for bone health.
- - The findings suggest that higher levels of liver fibrosis are predictive of increased bone fragility, even after adjusting for other variables such as age, sex, and BMI, highlighting the importance of monitoring bone
Article Abstract
Background And Purpose: Chronic liver diseases are associated with increased bone fracture risk, mostly in end-stage disease and cirrhosis; besides, data in non-alcoholic fatty liver disease (NAFLD) are limited. Aim of this study was to investigate bone mineralization and microstructure in obese individuals with NAFLD in relation to the estimated liver fibrosis.
Methods: For this cross-sectional investigation, we analyzed data from 1872 obese individuals (44.6 ± 14.1 years, M/F: 389/1483; BMI: 38.3 ± 5.3 kg/m) referring to the Endocrinology outpatient clinics of Sapienza University, Rome, Italy. Participants underwent clinical work-up, Dual-Energy X-ray Absorptiometry for assessing bone mineral density (BMD) and microarchitecture (trabecular bone score, TBS). Liver fibrosis was estimated by Fibrosis Score 4 (FIB-4). Serum parathyroid hormone (PTH), 25(OH) vitamin D, osteocalcin and IGF-1 levels were measured.
Results: Obese individuals with osteopenia/osteoporosis had greater FIB-4 than those with normal BMD (p < 0.001). FIB-4 progressively increased in presence of degraded bone microarchitecture (p < 0.001) and negatively correlated with the serum osteocalcin (p < 0.001) and IGF-1 (p < 0.001), which were both reduced in presence of osteopenia/osteoporosis. FIB-4 predicted IGF-1 reduction in multivariable regression models adjusted for confounders (β: - 0.18, p < 0.001). Higher FIB-4 predicted bone fragility with OR 3.8 (95%C.I:1.5-9.3); this association persisted significant after adjustment for sex, age, BMI, diabetes, smoking status and PTH at the multivariable logistic regression analysis (OR 1.91 (95%C.I:1.15-3.17), p < 0.01), with AUROC = 0.842 (95%C.I:0.795-0.890; p < 0.001).
Conclusion: Our data indicate the presence of a tight relation between NAFLD-related liver fibrosis, lower bone mineral density and degraded microarchitecture in obese individuals, suggesting potential common pathways underlying liver and bone involvement in obesity and insulin resistance-associated disorders.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s12072-022-10461-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Assessment of myocardial infarctions knowledge, attitudes and beliefs among adults living in Riyadh Saudi Arabia - insights from cross-sectional study.
Sci Rep
December 2024
Department of Optometry, College of Applied Medical Sciences, King Saud University, Riyadh, 11451, Saudi Arabia.
Globally, the prevalence of coronary artery disease (CAD) is increasing, accounting for a third of all deaths worldwide including myocardial infarctions (MIs) which represent the most severe clinical manifestation of CAD and are among the most dangerous coronary events. Therefore, this study aims to assess the knowledge of symptoms and risk factors of MIs, as well as attitudes and beliefs regarding MIs and confidence in recognizing CAD symptoms in Riyadh, Saudi Arabia. A cross-sectional study was conducted among individuals living in Riyadh, Saudi Arabia between November 2023 and April 2024 to assess their knowledge and beliefs about CAD and MIs.
View Article and Find Full Text PDFA new perspective on bone development in vitamin D deficiency-associated obese children.
Sci Rep
December 2024
Affiliated Hospital of Jiangnan University, Wuxi, 214000, Jiangsu, China.
Vitamin D is crucial for maintaining bone health and development, and bone mineral accumulation during childhood and adolescence affects long-term bone health. Vitamin D deficiency has been widely recognized as one of the main causes of osteoporosis and fractures, especially during the growth and development stage of children. Recent studies have shown that vitamin D deficiency may affect the deviation of bone development in children by mediating lipid metabolism disorders, but its specific mechanism of action has not been fully elucidated.
View Article and Find Full Text PDFPersonality traits influence food cravings in pregnant women.
Sci Rep
December 2024
Department of Psychiatry, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia.
Food craving is a common phenomenon during pregnancy. This behaviour may be influenced by personality traits that have been known to be linked with obesity and addiction affecting pregnancy outcomes. We identified the prevalence of food cravings and evaluated its relationship with personality traits in pregnant women.
View Article and Find Full Text PDFPreliminary study of Kinesio Taping in rectus abdominis diastasis treatment and abdominal circumference improvement in postpartum women: a retrospective study.
Sci Rep
December 2024
Department of Obstetrics and Gynecology rehabilitation, West China Second Hospital, Sichuan University, Huaxi Technology Building, 16 Linjiang Middle Road, Wuhou District, Chengdu, 610000, Sichuan, China.
Rectus abdominis diastasis (RAD) is a key factor in the rehabilitation of postpartum women. This study aimed to evaluate the clinical efficacy of Kinesio Taping (KT) in RAD treatment and abdominal changes. The medical records of women with RAD who received KT treatment at the hospital were reviewed.
View Article and Find Full Text PDFBayesian semiparametric inference in longitudinal metabolomics data.
Sci Rep
December 2024
Department of Statistical Science, Duke University, Durham, 27708-0251, USA.
The article is motivated by an application to the EarlyBird cohort study aiming to explore how anthropometrics and clinical and metabolic processes are associated with obesity and glucose control during childhood. There is interest in inferring the relationship between dynamically changing and high-dimensional metabolites and a longitudinal response. Important aspects of the analysis include the selection of the important set of metabolites and the accommodation of missing data in both response and covariate values.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!