AI Article Synopsis
- Vitamin D is important not just for bone health, but also for regulating the immune system, blood pressure, diabetes, and heart diseases, with its effects mediated through binding to the vitamin D receptor (VDR).
- This study specifically examined the role of two genetic variations (SNPs rs2228570 and rs7975232) of the VDR in relation to cardiometabolic disorders among the Pakistani population, involving 400 patients and 226 healthy controls.
- Findings showed that the GG and AG genotypes of the rs2228570 polymorphism significantly increased the risk of hypertension in cardiovascular patients, while the rs7975232 polymorphism did not show any correlation with these conditions.
Article Abstract
Apart from bone related effects, vitamin D has roles in immune modulation, hypertension, diabetes and cardiovascular diseases. Metabolic functions of vitamin D are mediated after binding with vitamin D receptor (VDR). polymorphisms affect its physiological functions. Several single nucleotide polymorphisms (SNPs) were reported previously. However, VDR polymorphisms causing influence on cardiovascular and metabolic disorders have not been investigated in the Pakistani population so far. Therefore, the present study was conducted to evaluate the role of polymorphisms (rs2228570 and rs7975232) in the pathobiology of cardiometabolic disorders. In total, 400 cardiometabolic patients and 226 healthy control human adults were enrolled from Faisalabad, Pakistan. Biochemical parameters (serum glucose, liver function test, renal function test and lipid profile) were analyzed by standard kit methods. Genetic analysis was done by ARMS-PCR assay. Data was analyzed in SPSS v20. Regression analysis revealed that GG and AG genotypes of rs2228570 A>G polymorphism significantly increased the risk of hypertension in cardiovascular patients by 5.29 and 5.94 times respectively (GG: OR=5.29, 95% CI=1.63-17.2, ; AG: OR=5.94, 95% CI=1.70-20.7, ). However, rs7975232 C>A polymorphism was not correlated with cardiometabolic conditions. In conclusion, GG and AG genotypes of SNP rs2228570 significantly contribute to hypertension in cardiovascular disease patients.
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| http://dx.doi.org/10.1024/0300-9831/a000772 | DOI Listing |
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