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Validation of Dual-Color Dual In Situ Hybridization for HER2/neu Gene in Breast Cancer.
Arch Pathol Lab Med
April 2024
From the Department of Pathology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.
Context.—: Human epidermal growth factor (HER2/neu) gene amplification, a poor prognostic factor in invasive breast cancer, has shown substantial utility as a predictive marker, with significantly improved survival following anti-HER2 therapies like trastuzumab. Dual-color dual in situ hybridization (D-DISH), a recently introduced fully automated assay for HER2/neu evaluation on light microscopy, has several advantages over fluorescence in situ hybridization (FISH).
View Article and Find Full Text PDFThe Latest DISH: Thinking About Direct Discharge Home and Our Reception of the New and Good.
Crit Care Med
January 2023
Division of Pulmonary and Critical Care Medicine, University of Maryland School of Medicine, Baltimore, MD.
Cellular and Engineered Organoids for Cardiovascular Models.
Circ Res
June 2022
Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA (D.T., C.A., J.C.W.).
An ensemble of in vitro cardiac tissue models has been developed over the past several decades to aid our understanding of complex cardiovascular disorders using a reductionist approach. These approaches often rely on recapitulating single or multiple clinically relevant end points in a dish indicative of the cardiac pathophysiology. The possibility to generate disease-relevant and patient-specific human induced pluripotent stem cells has further leveraged the utility of the cardiac models as screening tools at a large scale.
View Article and Find Full Text PDFHuman embryos in a dish - modeling early embryonic development with pluripotent stem cells.
Cell Regen
January 2022
Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences Research Triangle Park, Durham, NC, 27709, USA.
Stem cell-based embryo models present new opportunities to study early embryonic development. In a recent study, Kagawa et al. identified an approach to create human pluripotent stem cell-based blastoids that resemble the human blastocysts.
View Article and Find Full Text PDFIs activation of GDNF/RET signaling the answer for successful treatment of Parkinson's disease? A discussion of data from the culture dish to the clinic.
Neural Regen Res
July 2022
Institute of Translational and Stratified Medicine, Peninsula Medical School, Faculty of Health, University of Plymouth, Devon, UK.
The neurotrophic signaling of glial cell line-derived neurotrophic factor (GDNF) with its canonical receptor, the receptor tyrosine kinase RET, coupled together with the GDNF family receptor alpha 1 is important for dopaminergic neuron survival and physiology in cell culture experiments and animal models. This prompted the idea to try GDNF/RET signaling as a therapeutic approach to treat Parkinson's disease with the hallmark of dopaminergic cell death in the substantia nigra of the midbrain. Despite several clinical trials with GDNF in Parkinson's disease patients, which mainly focused on optimizing the GDNF delivery technique, benefits were only seen in a few patients.
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