The novel HLA-A*03:440 allele was characterized using next generation sequencing technology.
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Genomic profiles and their relationships with clinical characteristics and immune features in cervical cancer.
Transl Oncol
June 2024
Xinjiang Medical University Affiliated Tumor Hospital, Key Laboratory of Cancer Immunotherapy and Radiotherapy, Chinese Academy of Medical Sciences, Urumqi, Xinjiang 830011, China; Key Laboratory of Oncology of Xinjiang Uyghur Autonomous Region, Urumqi, Xinjiang 830011, China; Xinjiang Uygur Autonomous Region Radiotherapy Clinical Research and Training Center, The Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830011, China. Electronic address:
Objective: This study aimed to investigate the genomic alteration profiles of cervical cancer patients, examine the correlation between mutation patterns and clinical and immune attributes, and discover novel targets for treatment of individuals with cervical cancer.
Methods: We performed targeted next-generation sequencing of tumor tissues and blood samples obtained from 45 cervical cancer patients to analyze somatic alterations, mutation patterns, and HLA alleles comprehensively. Additionally, we used flow cytometry to assess expression levels of immune checkpoint genes.
Identification of novel canonical and cryptic HCMV-specific T-cell epitopes for HLA-A∗03 and HLA-B∗15 via peptide-PRISM.
Blood Adv
February 2024
Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany.
Human cytomegalovirus (HCMV) reactivation poses a substantial risk to patients receiving tranplants. Effective risk stratification and vaccine development is hampered by a lack of HCMV-derived immunogenic peptides in patients with common HLA-A∗03:01 and HLA-B∗15:01 haplotypes. This study aimed to discover novel HCMV immunogenic peptides for these haplotypes by combining ribosome sequencing (Ribo-seq) and mass spectrometry with state-of-the-art computational tools, Peptide-PRISM and Probabilistic Inference of Codon Activities by an EM Algorithm.
View Article and Find Full Text PDFNovel association of five HLA alleles with HIV-1 progression in Spanish long-term non progressor patients.
PLoS One
March 2020
National Center for Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
Certain host genetic variants, especially in the human leucocyte antigen (HLA) region, are associated with different progression of HIV-1-induced diseases and AIDS. Long term non progressors (LTNP) represent only the 2% of infected patients but are especially relevant because of their efficient HIV control. In this work we present a global analysis of genetic data in the large national multicenter cohort of Spanish LTNP, which is compared with seronegative individuals and HIV-positive patients.
View Article and Find Full Text PDFHLA-A*24:374-A novel allele encoding the HLA-A2403 specificity.
HLA
April 2017
Welsh Transplantation and Immunogenetics Laboratory, Welsh Blood Service, Pontyclun, Wales, UK.
HLA-A*24:374 differs from A*24:03:01:01 by 2 exon 3 bases resulting in a substitution of T163E.
View Article and Find Full Text PDFNovel Associations Between Major Histocompatibility Complex and Pediatric-onset Inflammatory Bowel Disease.
J Pediatr Gastroenterol Nutr
April 2016
*Children's Hospital †Transplantation Laboratory, Haartman Institute ‡Gastrointestinal Surgery §Immunobiology Research Program, Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki and Helsinki University Hospital, Finland.
Purpose: Major histocompatibility complex (MHC) genes have been widely studied in adult inflammatory bowel disease (IBD), but data on MHC genes are scarce in pediatric IBD. This study focused on MHC association of genes with pediatric-onset IBD and its different phenotypes.
Methods: Blood samples of 103 patients with pediatric IBD (Crohn disease or ulcerative colitis) were collected at Children's Hospital, University of Helsinki, Finland.
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