AI Article Synopsis
- Research shows miRNA-128 (miR-128) plays a crucial role in the initiation and development of various cancers, impacting immune responses.
- There is potential for miR-128 to be used as a biomarker and a focus for new anticancer treatments due to its abnormal expression in tumors.
- The review explores miR-128's role in multiple cancers and discusses its influence on resistance to treatments and immunotherapy through exosomes.
Article Abstract
Increasing data have shown the significance of various miRNAs in malignancy. In this regard, parallel to its biological role in normal tissues, miRNA-128 (miR-128) has been found to play an essential immunomodulatory function in the process of cancer initiation and development. The occurrence of the aberrant expression of miR-128 in tumors and the unique properties of miRNAs raise the prospect of their use as biomarkers and the next generation of molecular anticancer therapies. The function of miR-128 in malignancies such as breast, prostate, colorectal, gastric, pancreatic, esophageal, cervical, ovarian and bladder cancers and hepatocellular carcinoma is discussed in this review. Finally, the effect of exosomal miR-128 on cancer resistance to therapeutics and cancer immunotherapy in certain malignancies is highlighted.
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| http://dx.doi.org/10.2217/fon-2022-0574 | DOI Listing |
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