AI Article Synopsis
- A study was conducted to evaluate the effectiveness and safety of nivolumab immunotherapy in patients with recurrent or metastatic oral squamous cell carcinoma.
- The research involved 143 patients and found that nivolumab achieved a 27.3% overall response rate and a disease control rate of 46.2%.
- Key factors influencing patient survival included performance status and the occurrence of immune-related side effects, with overall survival averaging about 11.2 months, indicating nivolumab is an effective and well-tolerated treatment option.
Article Abstract
Objectives: Immunotherapy with nivolumab for patients with recurrent/metastatic oral squamous cell carcinoma has not been evaluated. Here, we aimed to examine the efficacy, safety, and prognostic factors of nivolumab in these patients.
Materials And Methods: This multicenter retrospective observational study involved patients who received nivolumab between April 2017 and June 2019. The patient characteristics were evaluated for association with progression-free and overall survival. Progression-free and overall survival rates were calculated; parameters that were significant in the univariate analysis were used as explanatory variables. Independent factors for progression-free and overall survival were identified using multivariate analysis.
Results: Totally, 143 patients were included. The overall response and disease control rates were 27.3% and 46.2%, respectively. The median, 1- and 2-year progression-free survival rates were 2.7 months, 25.4%, and 19.2%, respectively; those for overall survival were 11.2 months, 47.3%, and 33.6%, respectively. The independent factors affecting progression-free survival were performance status and immune-related adverse event occurrence, whereas those affecting overall survival were performance status, target disease, and number of previous lines of systemic cancer therapy. Eight patients reported grade ≥3 immune-related adverse events.
Conclusion: Nivolumab was effective for recurrent/metastatic oral squamous cell carcinoma treatment and was well tolerated by patients.
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| http://dx.doi.org/10.1111/odi.14471 | DOI Listing |
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