RUNX3 is a transcription factor and tumor suppressor that is silenced or inactivated in diverse tumors. The effect of RUNX3 on the epithelial-mesenchymal transition in clear-cell renal cell carcinoma (CCRCC) remains unclear. We determined the expression of and E-cadherin in tumor tissues and adjacent normal tissues of 30 CCRCC patients; established cultured CCRCC cells with the overexpression of ; and examined the tumorigenic function of in a nude mouse xenograft model of CCRCC. and E-cadherin were downregulated in human CCRCC samples. Cell lines with overexpression had reduced cell proliferation, invasion, and migration, a prolonged cell cycle, increased apoptosis, and increased expression of E-cadherin. In the nude mouse xenograft model of CCRCC, tumors with the overexpression of had smaller volumes and weights and had increased expression of E-cadherin. In conclusion, overexpression increased the level of E-cadherin and inhibited the proliferation, invasion, and migration of CCRCC and . has potential use as a biomarker for prognostic monitoring of CCRCC and as a therapeutic target for the treatment of this cancer.
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| http://dx.doi.org/10.1515/biol-2022-0494 | DOI Listing |
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