RNA mA modification: Mapping methods, roles, and mechanisms in acute myeloid leukemia.

N-Methyladenosine (mA) is the most abundant modification in eukaryotic mRNA, and plays important biological functions via regulating RNA fate determination. Recent studies have shown that mA modification plays a key role in hematologic malignancies, including acute myeloid leukemia. The current growth of epitranscriptomic research mainly benefits from technological progress in detecting RNA mA modification in a transcriptome-wide manner. In this review, we first briefly summarize the latest advances in RNA mA biology by focusing on writers, readers, and erasers of mA modification, and describe the development of high-throughput methods for RNA mA mapping. We further discuss the important roles of mA modifiers in acute myeloid leukemia, and highlight the identification of potential inhibitors for AML treatment by targeting of mA modifiers. Overall, this review provides a comprehensive summary of RNA mA biology in acute myeloid leukemia.