Deep learning-based speech analysis for Alzheimer's disease detection: a literature review.

Background: Alzheimer's disease has become one of the most common neurodegenerative diseases worldwide, which seriously affects the health of the elderly. Early detection and intervention are the most effective prevention methods currently. Compared with traditional detection methods such as traditional scale tests, electroencephalograms, and magnetic resonance imaging, speech analysis is more convenient for automatic large-scale Alzheimer's disease detection and has attracted extensive attention from researchers. In particular, deep learning-based speech analysis and language processing techniques for Alzheimer's disease detection have been studied and achieved impressive results.

Methods: To integrate the latest research progresses, hundreds of relevant papers from ACM, DBLP, IEEE, PubMed, Scopus, Web of Science electronic databases, and other sources were retrieved. We used these keywords for paper search: (Alzheimer OR dementia OR cognitive impairment) AND (speech OR voice OR audio) AND (deep learning OR neural network).

Conclusions: Fifty-two papers were finally retained after screening. We reviewed and presented the speech databases, deep learning methods, and model performances of these studies. In the end, we pointed out the mainstreams and limitations in the current studies and provided a direction for future research.