Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10031766 | PMC |
| http://dx.doi.org/10.1016/j.tips.2022.11.007 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effect of two novel GABAA receptor positive allosteric modulators on neuropathic and inflammatory pain in mice.
Neuropharmacology
January 2025
Department of Pharmacy, Nanjing First Hospital, Nanjing Medical University, Nanjing, China; School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China. Electronic address:
Loss of GABAergic inhibition in the spinal dorsal horn (SDH) is implicated in central sensitization and chronic pain. Both agonists and positive allosteric modulators (PAMs) of GABAA receptor are found to be effective in the management of chronic pain. In addition to benzodiazepines, neuroactive steroids (NASs) also act as PAMs through binding to unique sites of GABAA receptors.
View Article and Find Full Text PDFThe Emerging Role of Neurosteroids: Novel Drugs Brexanalone, Sepranolone, Zuranolone, and Ganaxolone in Mood and Neurological Disorders.
Cureus
July 2024
Psychiatry and Behavioral Sciences, Sri Ramachandra Institute of Higher Education and Research, Chennai, IND.
Article Synopsis
- * Brexanolone and zuranolone are particularly effective for postpartum depression, providing rapid symptom relief through their action on the GABA system, as shown in clinical trials.
- * Beyond mood disorders, ganaxalone shows promise for managing epilepsy by controlling seizures via GABAergic activity, and neurosteroids may offer neuroprotection in Alzheimer's models, suggesting their potential to mitigate excitotoxicity and slow neurodegeneration.
Caregiver Perspective of Benefits and Side Effects of Anti-Seizure Medications in CDKL5 Deficiency Disorder from an International Database.
CNS Drugs
September 2024
Telethon Kids Institute, Centre for Child Health Research, The University of Western Australia, 15 Hospital Avenue, Nedlands, Perth, WA, 6009, Australia.
Background And Objective: CDKL5 deficiency disorder presents as a challenging condition with early-onset refractory seizures, severe developmental delays, and a range of other neurological symptoms. Our study aimed to explore the benefits and side effects of anti-seizure medications (ASMs) in managing seizures among individuals with CDKL5 deficiency disorder, drawing on data from the International CDKL5 Disorder Database.
Methods: Data for this retrospective cohort study were obtained from the International CDKL5 Disorder Database, which contains responses from a baseline questionnaire administered between 2012 and 2022 and a follow-up questionnaire administered between 2018 and 2019.
Development and internal validation of a clinical risk score to predict incident renal and pulmonary tumours in people with tuberous sclerosis complex.
J Med Genet
September 2024
CRCHUM, Montreal, Quebec, Canada
Article Synopsis
- The study aims to create and validate a clinical risk score to predict renal angiomyolipoma (AML) and pulmonary lymphangioleiomyomatosis (LAM) in patients with tuberous sclerosis complex (TSC).
- Data from 2420 participants was analyzed using logistic regression, taking into account early-onset clinical signs, sex, and genetic mutations to develop risk scores for AML and LAM.
- Results showed that risk scores effectively predicted the likelihood of AML and LAM, with excellent calibration and strong discrimination, suggesting potential for personalized preventative care and screening in TSC patients.
Effects of ganaxolone on non-seizure outcomes in CDKL5 Deficiency Disorder: Double-blind placebo-controlled randomized trial.
Eur J Paediatr Neurol
July 2024
Charles Shor Epilepsy Center, Cleveland Clinic Neurological Institute, Cleveland, OH, USA.
CDKL5 deficiency disorder (CDD) is a rare developmental and epileptic encephalopathy. Ganaxolone, a neuroactive steroid, reduces the frequency of major motor seizures in children with CDD. This analysis explored the effect of ganaxolone on non-seizure outcomes.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!