AI Article Synopsis
- * This process facilitated the creation of chiral 3-amino DMAP catalysts.
- * The resulting enantioenriched DMAP was effectively utilized in an asymmetric reaction, producing 3,3-disubstituted benzofuran-2-ones with a yield of up to 96% and an enantiomeric excess (ee) of 97%.
Article Abstract
A CuI-catalyzed C-N coupling reaction of 3-bromo-DMAP with l-prolinamides was conducted at 80 °C in 12-16 h, where the prolinamide's structure had an accelerating effect on the Ullmann-type reaction. This reaction was used to construct chiral 3-amino DMAP catalysts. Furthermore, enantioenriched DMAP analogue was applied in an asymmetric Black rearrangement of 2-benzofuranylcarbonates, affording 3,3-disubstituted benzofuran-2-ones in up to 96% yield and 97% ee.
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| http://dx.doi.org/10.1021/acs.joc.2c02368 | DOI Listing |
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