AI Article Synopsis

  • Fertility preservation (FP) services for cancer patients, particularly child, adolescent, and young-adult (CAYA) patients, are increasingly utilized in Japan, but data on its usage rates and outcomes were previously lacking.
  • The Japan Society for Fertility Preservation launched the Japan Oncofertility Registry (JOFR) in 2018 to gather detailed information on patients' diseases, FP treatments, and outcomes, with analysis conducted up to 2021.
  • As of 2021, 1,244 patients received FP counseling or treatment, with notable trends showing that most female patients were aged 31-40 and that leukemia and breast cancer were the most common diagnoses among male and female patients, respectively; over 700

Article Abstract

Fertility preservation (FP) is becoming increasingly common among child, adolescent, and young-adult (CAYA) patients with cancer. However, Japan has long lacked definite estimates of utilization rates for FP services among CAYA patients with cancer, and little is known about disease/FP outcomes among users. Therefore, the Japan Society for Fertility Preservation (JSFP) launched the Japan Oncofertility Registry (JOFR) in 2018 and started the online registration of information regarding primary disease, FP, and data on prognosis and pregnancy outcomes. This study reports the analytical results of FP data registered in the JOFR as of 2021. Data about patients' primary disease(s), treatment courses, cancer and pregnancy outcomes, and specific procedures were extracted from the JOFR and analyzed. In 2021, 1244 patients received counseling or treatment related to FP (540 males, 704 females). While the numbers of males in each age group were approximately equal, most females were aged between 31 and 40 years. In total, 490 male and 540 female patients underwent FP procedures. Leukemia, testicular cancer, and malignant lymphoma accounted for the majority of male cases seeking treatment, whereas breast cancer was the primary disease in two-thirds of the females. Since 1999, 395 patients have accumulatively experienced subsequent pregnancy. As of January 2022, >7000 cases from >100 fertility facilities have been registered in the JOFR. In the future, maintaining JOFR to disseminate information on cancer prognoses, pregnancy rates, and other oncofertility outcomes is expected to drive further expansion of oncofertility services in Japan.

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Source
http://dx.doi.org/10.1089/jayao.2022.0110DOI Listing

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