Salicylic acid is an NSAID with serious side effects on the GIS. The side effects of salicylic acid on the GIS are slightly reduced by acetylating salicylic acid. 12 new ester analogs of salicylic acid were synthesized with high yields in this study. The chemical structures of the synthesized compounds were characterized by H-NMR, C-NMR, and HRMS spectra. The inhibitory potential of the compounds was evaluated on COXs by in vitro and in silico studies. The COX2 inhibitory activity of the most potent inhibitor MEST1 (IC : 0.048 μM) was found to be much higher than the COX2 inhibitory activity of aspirin (IC : 2.60 μM). In docking studies, the strongest inhibitor among the compounds synthesized was predicted to be MEST1, with the lowest binding energy. Docking studies revealed that MEST1 extends from the hydrophobic channel to the top of the cyclooxygenase active site, forming various interactions with residues in the binding pocket.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/cbdv.202200509 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Volatile cues of enhanced attractiveness to Parapanteles hyposidrae (Wilkinson) wasps mediated by jasmonic and salicylic acid pathways synergism in tea plant.
Pest Manag Sci
January 2025
Tea Research Institute, Chinese Academy of Agricultural Sciences, Ministry of Agriculture and Rural Affairs Key Laboratory of Tea Biology and Resource Utilization, Hangzhou, China.
Background: The jasmonic acid (JA) and salicylic acid (SA) pathways are often thought to interact antagonistically in plants when mediating anti-herbivore resistance. However, we previously found that the two pathways in tea plant interact synergistically when treated with 1.5 mmol/L methyl jasmonate (MeJA) and 20 mmol/L SA at 12 h intervals (MeJA+SA treatment).
View Article and Find Full Text PDFAssessment of salicylic acid and potassium nitrate to mitigate frost stress in autumn-sown potato crop cv. Sutlej.
Sci Rep
January 2025
Department of Agronomy, Faculty of Agriculture and Environment, The Islamia University of Bahawalpur, Bahawalpur, 63100, Pakistan.
Potato is cultivated all the year round in Pakistan. However, the major crop is the autumn crop which is planted in mid-October and contributes 80-85% of the total production. The abrupt climate change has affected the weather patterns all over the world, resulting in the reduction of the mean air temperature in autumn by almost 1.
View Article and Find Full Text PDFDrug Property Optimization: Design, Synthesis, and Characterization of Novel Pharmaceutical Salts and Cocrystal-Salt of Lumefantrine.
Mol Pharm
January 2025
Department of Industrial and Molecular Pharmaceutics, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States.
Lumefantrine (LMF) is a low-solubility antimalarial drug that cures acute, uncomplicated malaria. It exerts its pharmacological effects against erythrocytic stages of spp. and prevents malaria pathogens from producing nucleic acid and protein, thereby eliminating the parasites.
View Article and Find Full Text PDFIntegrated role of biochar and PGPR (Leclercia adecarboxylata HW04) in enhancing cadmium phytoremediation and stress tolerance in Glycine max L.
Plant Physiol Biochem
January 2025
Department of Applied Biosciences, Kyungpook National University, 41566, Daegu, Republic of Korea. Electronic address:
Plant growth-promoting rhizobacteria (PGPR) and biochar (BC) are recognized as effective biological agents for enhancing stress tolerance and mitigating heavy metal toxicity in crops. Therefore, this study aims to investigate the effects of the cadmium (Cd)-resistant PGPR strain Leclercia adecarboxylata HW04 (>4 mM Cd resistance) on soybean plants exposed to 300 μM Cd. HW04 was observed to possess the innate ability to synthesize indole-3-acetic acid and exopolysaccharides, which facilitated the absorption of Cd in the medium.
View Article and Find Full Text PDFThe basal level of salicylic acid represses the PRT6 N-degron pathway to modulate root growth and stress response in rice.
Plant Commun
January 2025
State Key Laboratory of Efficient Utilization of Arid and Semi-arid Arable Land in Northern China, Institute of Agricultural Resources and Regional Planning, Chinese Academy of Agricultural Sciences, Beijing, China.
Maintaining a stable basal level of salicylic acid (SA) is crucial for plant growth, development, and stress response, though basal levels of SA vary significantly among plant species. However, the molecular mechanisms by which basal SA regulates plant growth and stress response remain to be elucidated. In this study, we performed a genetic screen to identify suppressors of the root growth defect in Osaim1, a rice mutant deficient in basal SA biosynthesis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!