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Electrochemical synthesis of vicinal azidoacetamides. | LitMetric

Electrochemical synthesis of vicinal azidoacetamides.

Chem Commun (Camb)

Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, Fuzhou University, Fuzhou 350108, China.

Published: January 2023

Vicinal diamines are an important structural motif in bioactive natural products and pharmaceutical intermediates. Herein, an environmentally friendly and efficient electrochemical approach to azidoacetamides, as one variant of vicinal diamines, has been developed. This reaction features mild conditions and broad substrate scope, without the use of any chemical oxidant or transition-metal catalysts. The obtained vicinal azidoacetamides could be conveniently converted into various other vicinal diamine derivatives.

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Source
http://dx.doi.org/10.1039/d2cc06246aDOI Listing

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