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Anesthesia and analgesia for common research models of adult mice. | LitMetric

AI Article Synopsis

  • Anesthesia and analgesia are often misreported or used interchangeably in animal research, which is unethical and leads to lower-quality studies.
  • This review focuses on the proper use of anesthetic and analgesic methods specifically for laboratory mice, ensuring correct practices in routine procedures.
  • It provides detailed dosing, pharmacological information, and discusses side effects of relevant drugs to guide researchers in making informed choices for their studies.

Article Abstract

Anesthesia and analgesia are major components of many interventional studies on laboratory animals. However, various studies have shown improper reporting or use of anesthetics/analgesics in research proposals and published articles. In many cases, it seems "anesthesia" and "analgesia" are used interchangeably, while they are referring to two different concepts. Not only this is an unethical practice, but also it may be one of the reasons for the proven suboptimal quality of many animal researches. This is a widespread problem among investigations on various species of animals. However, it could be imagined that it may be more prevalent for the most common species of laboratory animals, such as the laboratory mice. In this review, proper anesthetic/analgesic methods for routine procedures on laboratory mice are discussed. We considered the available literature and critically reviewed their anesthetic/analgesic methods. Detailed dosing and pharmacological information for the relevant drugs are provided and some of the drugs' side effects are discussed. This paper provides the necessary data for an informed choice of anesthetic/analgesic methods in some routine procedures on laboratory mice.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9746144PMC
http://dx.doi.org/10.1186/s42826-022-00150-3DOI Listing

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