Combining immune receptor engineering with conditional expression of accessory molecules holds great promise for advancing the field of cell-based immunotherapies. In this issue of Cancer Cell, Smole et al. introduce a modular single vector system to simultaneously redirect T cell specificity toward cancer antigens while achieving activation-gated delivery of customizable payloads.
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| http://dx.doi.org/10.1016/j.ccell.2022.11.012 | DOI Listing |
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Novel neuromuscular controllers with simplified muscle model and enhanced reflex modulation: A comparative study in hip exoskeletons.
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Biorobotics Laboratory, EPFL, Lausanne, Vaud, Switzerland.
Neuromuscular controllers (NMCs) offer a promising approach to adaptive and task-invariant control of exoskeletons for walking assistance, leveraging the bioinspired models based on the peripheral nervous system. This article expands on our previous development of a novel structure for NMCs with modifications to the virtual muscle model and reflex modulation strategy. The modifications consist firstly of simplifications to the Hill-type virtual muscle model, resulting in a more straightforward formulation and reduced number of parameters; and second, using a finer division of gait subphases in the reflex modulation state machine, allowing for a higher degree of control over the shape of the assistive profile.
View Article and Find Full Text PDFAccuracy (trueness and precision) of 3-dimensional virtual patients: an in vitro investigation of different facial scanners and digital integration techniques.
J Dent
January 2025
Department of Biologic and Materials Sciences & Prosthodontics, University of Michigan School of Dentistry, Ann Arbor, MI, USA. Electronic address:
Objectives: To investigate the influence of different facial scanners and integration approaches on the accuracy of virtual dental patients (VDPs).
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A sensitive post-column derivatization approach for enhancing hydroxyl metabolites detection.
Anal Chim Acta
February 2025
Department of Pharmacy, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan. Electronic address:
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View Article and Find Full Text PDFFormation and crystalline structure of spherulites from pea and high amylose maize starches.
Int J Biol Macromol
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Department of Grain Science and Industry, Kansas State University, Manhattan, KS 66506, USA. Electronic address:
Starch spherulite is a unique form of resistant starch characterized by a spherical structure with crystalline lamellae that are radially oriented and may find applications in delivery of nutrients and bioactives to the lower gastrointestinal tract. Formation of starch spherulites generally requires heating to a high temperature followed by quenching and long crystallization time. The objectives of this study were to gain a deeper understanding of the factors influencing spherulite formation from pea starch (PS) and high-amylose maize starch (HAMS) and investigate if spherulites could be formed by a slow cooling rate and determine the crystalline structure and morphology of the spherulites formed.
View Article and Find Full Text PDFIntegrated Decision and Motion Planning for Highways with Multiple Objects Using a Naturalistic Driving Study.
Sensors (Basel)
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Western Science City Intelligent and Connected Vehicle Innovation Center (Chongqing) Co., Ltd., Chongqing 400015, China.
With the rise in the intelligence levels of automated vehicles, increasing numbers of modules of automated driving systems are being combined to achieve better performance and adaptability by reducing information loss. In this study, an integrated decision and motion planning system is designed for multi-object highways. A two-layer structure is presented to decouple the influence of the traffic environment and the dynamic control of ego vehicles using the cognitive safety area, the size of which is determined by naturalistic driving behavior.
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