AI Article Synopsis
- Lynch syndrome typically connects to bowel tumours, but skin cancers, particularly squamous cell carcinoma, are rarely observed in patients.
- A case of a 40-year-old Sri Lankan man with a family history of colorectal cancer developed skin lesions diagnosed as squamous cell carcinoma two months post-surgery, yet he has remained disease-free for over two years.
- Awareness and education regarding potential skin malignancies are crucial for Lynch syndrome patients and their healthcare providers, given the link between defective mismatch repair genes and increased skin cancer risk.
Article Abstract
Introduction And Importance: Although synchronous and metachronous tumours of the bowel are well known associations of Lynch syndrome, the association of skin malignancies in such patients are extremely rare.
Case Presentation: A 40-year-old Sri Lankan man with a strong family history of colorectal cancer had an extended right hemicolectomy for a moderately differentiated adenocarcinoma. Two months after surgery, he developed two discrete ulcerative skin lesions in the chin and occipital region which excision biopsy confirmed to be squamous cell carcinoma. After more than two years of follow-up, patient remains disease free.
Clinical Discussion: The Muir Torre variant of Lynch syndrome is characteristically associated with sebaceous adenomas and carcinomas, though occurence of squamous cell carcinomas are rare. In reported cases, defective mismatch repair genes associated with Lynch syndrome may suggest an increased predisposition for squamous cell carcinomas.
Conclusion: Patients with Lynch syndrome should be educated on the importance of seeking an early medical consult for new skin lesions and raising awareness of this rare phenomenon for physicians involved in follow up is important.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763668 | PMC |
| http://dx.doi.org/10.1016/j.ijscr.2022.107822 | DOI Listing |
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