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Demonstrating the statistical and pharmacological sensitivity of nonclinical QTc analysis using a dofetilide dose-response in nonhuman primates.
J Pharmacol Toxicol Methods
December 2024
Charles River Laboratories, Mattawan, United States.
Nonclinical QTc studies can augment clinical QTc assessments in regulatory submissions provided they are of sufficient quality and sensitivity. Both the statistical performance and species translation play a role in determining the sensitivity of the model. The current analyses examine the effects of dofetilide or vehicle on the QT interval in nonhuman primate (NHP; n = 16) using a one-step estimated marginal means method where both treatment and animal ID are used in regression models to avoid a separate rate correction step, in comparison to other commonly utilized methods.
View Article and Find Full Text PDFExploring the ED50 and ED95 of Remimazolam for Laryngeal Mask Airway Insertion During General Anesthesia in Pediatric Strabismus Correction Surgery.
Ann Ital Chir
August 2024
Department of Anesthesiology, Ningbo No.2 Hospital, 315000 Ningbo, Zhejiang, China.
Article Synopsis
- The study investigated the effective doses (ED50 and ED95) of remimazolam for laryngeal mask airway insertion in pediatric patients undergoing strabismus correction surgery.
- It included 32 children aged 3-12 and employed a precise dosage method to determine the necessary amounts for effective sedation.
- Results showed that the ED50 was 0.300 mg/kg and ED95 was 0.369 mg/kg, with patients maintaining stable vital signs throughout the procedure, indicating safety and reliability for clinical use.
The feasibility of dexmedetomidine-led anesthesia maintenance strategy during major abdominal surgery.
Heliyon
March 2024
Department of Anesthesiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China.
Background: Dexmedetomidine is known for its selective action on α2-adrenoceptor sites and is recognized for its neuroprotective capabilities. It can improve postoperative cognitive function. Commonly used anesthetics, such as sevoflurane and propofol, have been reported to affect postoperative cognitive function.
View Article and Find Full Text PDFCalculation of effective dose of phenylephrine bolus for treatment of post-spinal hypotension in pre-eclamptic patients undergoing caesarean section - a non-randomised controlled trial.
Int J Obstet Anesth
November 2023
Department of Obstetrics and Gynaecology, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India.
Background: Patients with pre-eclampsia require smaller vasopressor doses compared with those with normotension for management of post-spinal hypotension during caesarean section. However, the literature has little evidence as to the phenylephrine dose required for patients with pre-eclampsia.
Methods: Fifty patients, with either pre-eclampsia or normotension, and developing post-spinal hypotension during caesarean section under spinal anaesthesia, were studied.
Physiological Basis for Using Vitamin D to Improve Health.
Biomedicines
May 2023
Medicine, Endocrinology & Nutrition, Cardio Metabolic Institute, (Former) Rutgers University, North Brunswick, NJ 08901, USA.
Vitamin D is essential for life-its sufficiency improves metabolism, hormonal release, immune functions, and maintaining health. Vitamin D deficiency increases the vulnerability and severity of type 2 diabetes, metabolic syndrome, cancer, obesity, and infections. The active enzyme that generates vitamin D [calcitriol: 1,25(OH)D], CYP27B1 (1α-hydoxylase), and its receptors (VDRs) are distributed ubiquitously in cells.
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