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[RSV and associated diseases]. | LitMetric

AI Article Synopsis

  • Respiratory syncytial virus (RSV) can reinfect individuals, even those who are immunized, due to its viral proteins interfering with the immune response rather than significant genetic changes.* -
  • After a 3 to 8-day incubation, RSV primarily causes nasopharyngitis and leads to excessive mucus production and damage to respiratory cells, impairing mucociliary transport.* -
  • The most common clinical consequence of RSV, especially in infants, is bronchiolitis, often requiring hospitalization, while acute otitis media is a frequent secondary complication that results in antibiotic prescriptions.*

Article Abstract

Similarly to many respiratory viruses, respiratory syncytial virus (RSV) is surprising in its ability to reinfect children and adults who have already been immunized. It is not so much in the evolution of its genome that we must look for the cause, but more probably in the structure/function of its viral proteins, which are capable of interfering with the immune response and memory. After an incubation of three to eight days, RSV infection most often results in nasopharyngitis with little or no fever. RSV infection of the respiratory epithelium is characterized by marked mucus production, desquamation of infected respiratory cells and persistent impairment of mucociliary transport. The extension of the infection to the lower respiratory tract therefore contributes to the formation of mucous plugs obstructing the lumen of the bronchioles. This is the cause of the clinical most commonly associated with RSV infection: bronchiolitis in newborns and infants which is a frequent reason for hospitalization due to secondary respiratory and digestive complications. The recent data from the literature, however, indicate that by far the most frequent complication is a community infection: acute otitis media. RSV infections are therefore a very common reason for the prescription of antibiotics.

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