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Alzheimers Dement
December 2024
Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Background: Alzheimer's Disease (AD) is a common form of dementia among the elderly with a large percentage of estimated heritability. Conventional polygenic risk analysis only accounts for the linearly combined genomic effects of single nucleotide polymorphisms (SNPs). On the other hand, a deep-learning-based approach is able to uncover nonlinearly associated effects from data with high-dimensional features such as genomics.
View Article and Find Full Text PDFGenome-wide analyses provide insights into genetic variation, phylo- and co-phylogenetic relationships, and biogeography of the entomopathogenic nematode genus Heterorhabditis.
Mol Phylogenet Evol
January 2025
Laboratory of Diagnosis and Integrated Management of Plant Bio-Aggressors. University of Parakou, BP123 Parakou, Borgou, Benin.
Multigene, genus-wide phylogenetic studies have uncovered the limited taxonomic resolution power of commonly used gene markers, particularly of rRNA genes, to discriminate closely related species of the nematode genus Heterorhabditis. In addition, conflicting tree topologies are often obtained using the different gene markers, which limits our understanding of the phylo- and co-phylogenetic relationships and biogeography of the entomopathogenic nematode genus Heterorhabditis. Here we carried out phylogenomic reconstructions using whole nuclear and mitochondrial genomes, and whole ribosomal operon sequences, as well as multiple phylogenetic reconstructions using various single nuclear and mitochondrial genes.
View Article and Find Full Text PDFAn intron-split microRNA mediates cleavage of the mRNA encoded by low phosphate root in Solanaceae.
Planta
January 2025
School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, UK.
A microRNA with a non-canonical precursor structure harbours an intron in between its miRNA-5p and miRNA-3p relevant for its biogenesis, is conserved across Solanaceae, and targets the mRNA of low phosphate root. Hundreds of miRNAs have been identified in plants and great advances have been accomplished in the understanding of plant miRNA biogenesis, mechanisms and functions. Still, many miRNAs, particularly those with less conventional features, remain to be discovered.
View Article and Find Full Text PDFA Pilot Study to Evaluate the Minimally Invasive Burn Care for Small, Deep Partial-Thickness Burns of the Hands and Feet Using Enzyme Debridement and Autologous Skin Cell Spray.
J Clin Med
December 2024
Department of Plastic and Reconstructive Surgery, Tokyo Medical University, Tokyo 160-0023, Japan.
: We treated deep partial-thickness burns of the hands and feet in four cases using a combination of NexoBrid and ReCell autologous cell regeneration techniques, without conventional split-thickness skin graft, with good results following debridement of the eschar. : We report cases of patients treated with a combination of the NexoBrid and ReCell techniques between 1 August 2023 and 31 July 2024. The degree of debridement and the time to complete wound closure were evaluated.
View Article and Find Full Text PDF[Analysis of difficulties in diagnosis and treatment of cracked tooth and research progress].
Zhonghua Kou Qiang Yi Xue Za Zhi
January 2025
Department of Cariology and Endodontology, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology, Beijing100081, China.
The occurrence of cracked tooth is closely related to the abnormal occlusal force. The cracks existing on hard tissue of tooth cannot be self-limiting. As long as the external force exists, the cracks would continue to expand, involving the pulp, periapical, and periodontal tissues, ultimately leading to splitting and tooth loss.
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