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Cordycepin and Its Structural Derivatives Effectively Suppress the High Expression of Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase in Breast Carcinomas: A Computational Drug Development Approach.
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Laboratory of Pharmaceutical Biotechnology and Bioinformatics, Department of Genetic Engineering and Biotechnology, Jashore University of Science and Technology, Jashore, 7408, Bangladesh.
Background: Breast cancer is a frequently diagnosed malignant disease and the primary cause of mortality among women with cancer worldwide. The therapy options are influenced by the molecular subtype due to the intricate nature of the condition, which consists of various subtypes. By focusing on the activation of receptors, Epidermal Growth Factor Receptor (EGFR) tyrosine kinase can be utilized as an effective drug target for therapeutic purposes of breast cancer.
View Article and Find Full Text PDFMulti-modal integration of MRI and global chamber charge density mapping for the evaluation of atrial fibrillation.
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Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford OX3 7DQ, UK.
Atrial fibrillation (AF) is the most prevalent clinical arrhythmia, posing significant mortality and morbidity challenges. Outcomes of current catheter ablation treatment strategies are suboptimal, highlighting the need for innovative approaches. A major obstacle lies in the inability to comprehensively assess both structural and functional remodelling in AF.
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Agronomy Section, Faculty of Agriculture, Khon Kaen University, Khon Kaen, Thailand.
To achieve good agricultural practices and maximize the economic yield of corn, farmers should reduce the use of inorganic fertilizers. A field experiment was conducted in the Chonnabot district, Khon Kaen province, Thailand, during the 2022 and 2023 growing seasons. The aim was to assess the impact of different organic fertilizers and their combinations on the growth and yield of commercial sweet corn ( L.
View Article and Find Full Text PDFActivated sludge prokaryote and eukaryote characterization in a pulp mill facility using amplicon sequencing.
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Bioinformatics Unit, Institut Pasteur de Montevideo, Montevideo, Uruguay.
The pulp and paper industry, a major global sector, supports economies and jobs while contributing to various products. While providing valuable products, and despite Best Available Techniques (BAT) being used, managing wastewater effectively remains a key area for developing technologies and alternatives for environmental protection. Activated sludge (AS) systems are commonly used for effluent treatment, where microorganisms composition influences reactor efficiency.
View Article and Find Full Text PDFDiagnostic Challenges and Insights Into Granulomatous Mastitis: A Systematic Review.
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Oncology/Radiation Oncolgy, Tawam Hospital, Al Ain, ARE.
Granulomatous mastitis (GM) is a chronic inflammatory breast condition that presents significant diagnostic challenges due to its clinical and imaging similarities to malignancies. Accurate diagnosis is crucial to avoid unnecessary interventions and ensure effective management. A total of 1,216 articles were initially identified through a comprehensive database search.
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