AI Article Synopsis
- * The study explores the use of multiphoton microscopy (MPM) to detect changes in lymph nodes after chemotherapy, finding distinct differences in collagen structure between normal and residual cancerous nodes.
- * MPM shows potential in assessing treatment response, which could lead to more personalized adjuvant therapies for breast cancer patients.
Article Abstract
Neoadjuvant treatment is often considered in breast cancer patients with axillary lymph node involvement, but most of patients do not have a pathologic complete response to therapy. The detection of residual nodal disease has a significant impact on adjuvant therapy recommendations which may improve survival. Here, we investigate whether multiphoton microscopy (MPM) could identify the pathological changes of axillary lymphatic metastasis after neoadjuvant chemotherapy in breast cancer. And furthermore, we find that there are obvious differences in seven collagen morphological features between normal node and residual axillary disease by combining with a semi-automatic image processing method, and also find that there are significant differences in four collagen features between the effective and no-response treatment groups. These research results indicate that MPM may help estimate axillary treatment response in the neoadjuvant setting and thereby tailor more appropriate and personalized adjuvant treatments for breast cancer patients.
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| http://dx.doi.org/10.1002/jbio.202200274 | DOI Listing |
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