AI Article Synopsis
- - The study investigates how renal denervation (RDN) affects ventricular arrhythmia after an acute myocardial infarction (AMI) in rats, aiming to understand the underlying mechanisms behind this effect.
- - Results show that RDN significantly decreases ventricular tachycardia occurrences, reduces sympathetic nerve activity, and alters neurotransmitter levels, including lowering norepinephrine and raising γ-aminobutyric acid (GABA) in the hypothalamus.
- - The conclusion suggests that RDN's protective effect against arrhythmia after AMI likely operates through the suppression of central sympathetic nerve activity.
Article Abstract
Background: Renal denervation (RDN) can reduce ventricular arrhythmia after acute myocardial infarction (AMI), but the mechanism is not clear. The purpose of this study is to study its mechanism.
Methods: Thirty-two Sprague-Dawley rats were divided into four groups: control group, AMI group, RDN-1d + AMI group, RDN-2w + AMI group. The AMI model was established 1 day after RDN in the RDN-1d + AMI group and 2 weeks after RDN in the RDN-2w + AMI group. At the same time, 8 normal rats were subjected to AMI modelling (the AMI group). The control group consisted of 8 rats without RDN intervention or AMI modelling.
Results: The study confirmed that RDN can reduce the occurrence of ventricular tachycardia in AMI rats, reduce renal sympathetic nerve discharge, and inhibit the activity of local sympathetic nerves and cell growth factor (NGF) protein expression in the heart after AMI. In addition, RDN decreased the expression of norepinephrine (NE) and glutamate in the hypothalamus,and NE in cerebrospinal fluid, and increased the expression level of γ aminobutyric acid (GABA) in the hypothalamus after AMI.
Conclusion: RDN can effectively reduce the occurrence of ventricular arrhythmia after AMI, and its main mechanism may be via the inhibition of central sympathetic nerve discharge.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743565 | PMC |
| http://dx.doi.org/10.1186/s12872-022-02980-4 | DOI Listing |
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