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FLASH radiotherapy combined with immunotherapy: From biological mechanisms to blockbuster therapeutics.
Transl Oncol
January 2025
Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China. Electronic address:
Article Synopsis
- FLASH ultra-high dose rate radiotherapy (RT) minimizes damage to normal tissues while effectively targeting tumors, resulting in a marked difference in treatment outcomes, commonly referred to as the FLASH effect.* -
- Various hypotheses explain the FLASH effect, such as oxygen depletion and immune protection, and recent studies suggest combining FLASH RT with immune checkpoint inhibitors (ICIs) could enhance immune responses against tumors.* -
- Despite its potential, the integration of FLASH RT with ICI therapy faces challenges like technical issues and lack of comprehensive data, indicating a need for further research in this area.*
Comparative analysis of LMA Blockbuster clinical performance: Blind versus Miller laryngoscope-guided insertion in paediatric general anaesthesia - A double-blinded, randomised controlled trial.
Indian J Anaesth
October 2024
Department of Anaesthesiology, Government Medical College, Pali, Rajasthan, India.
Article Synopsis
- The study compares two insertion methods for the LMA Blockbuster in children: blind insertion versus Miller laryngoscope-guided insertion, focusing on oropharyngeal leak pressure (OPLP) as the primary outcome.
- Results showed that guided insertion had a significantly higher mean OPLP (27.9 cmHO) compared to blind insertion (25.94 cmHO), indicating better airway positioning.
- While guided insertion took longer (11.9 seconds) than blind insertion (8.7 seconds), there were no significant differences in first-attempt success, haemodynamic stability, or postoperative complications.
Sequential responsive nano-PROTACs for precise intracellular delivery and enhanced degradation efficacy in colorectal cancer therapy.
Signal Transduct Target Ther
October 2024
Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 100191, Beijing, China.
PROteolysis TArgeting Chimeras (PROTACs) have been considered the next blockbuster therapies. However, due to their inherent limitations, the efficacy of PROTACs is frequently impaired by limited tissue penetration and particularly insufficient cellular internalization into their action sites. Herein, based on the ultra-pH-sensitive and enzyme-sensitive nanotechnology, a type of polymer PROTAC conjugated and pH/cathepsin B sequential responsive nanoparticles (PSRNs) are deliberately designed, following the construction of the PROTAC for Cyclin-dependent kinase 4 and 6 (CDK4/6).
View Article and Find Full Text PDFChoice of supraglottic airway devices: a network meta-analysis of randomised controlled trials.
Br J Anaesth
December 2024
Washington University in Saint Louis, Anaesthesiology Barnes Jewish Hospital, Saint Louis, MO, USA. Electronic address:
Background: Over the last two decades, significant research interest has led to the development of a wide variety of supraglottic airways (SGAs) for anaesthesia providers to choose from.
Methods: In this network meta-analysis, we analysed 111 studies, enrolling 12 045 patients undergoing airway management with 29 SGAs. We targeted outcomes that contribute to clinicians' choice of one SGA over another.
Weight Loss Blockbuster Development: A Role for Unimolecular Polypharmacology.
Annu Rev Pharmacol Toxicol
September 2024
1Department of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai, China; email:
Obesity and type 2 diabetes mellitus (T2DM) impact more than 2.5 billion adults worldwide, necessitating innovative therapeutic approaches. Unimolecular polypharmacology, which involves designing single molecules to target multiple receptors or pathways simultaneously, has revolutionized treatment strategies.
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