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Integrated virtual screening and compound generation targeting H275Y mutation in the neuraminidase gene of oseltamivir-resistant influenza strains.
Mol Divers
March 2025
Growdea Technologies Pvt. Ltd., Gurugram, Haryana, 122004, India.
Neuraminidase (NA) is an essential enzyme located at the outer layer of the influenza virus and plays a key role in the release of virions from infected cells. The rising incidence of global epidemics has made the urgent need for effective antiviral medications an urgent public health priority. Furthermore, the emergence of resistance caused by specific mutations in the influenza viral genome exacerbates the challenges of antiviral therapy.
View Article and Find Full Text PDFPhysicochemical and rheological characteristics of commercial Greek-style yogurt enriched with Polygonum cuspidatum roots or the P. Cuspidatum β-cyclodextrin inclusion complex.
Food Res Int
February 2025
Departamento de Preparatoria Agrícola y Posgrado en Ciencia y Tecnología Agroalimentaria, Universidad Autónoma Chapingo, km. 38.5 Carretera México Texcoco, Edo. México 56230, México.
In this work, the effects of enriching commercial Greek-style yogurt with β-cyclodextrin-encapsulated Polygonum cuspidatum hydroalcoholic extract powder (YE) or P. cuspidatum root powder (YR) on the physicochemical properties of yogurt were compared. Greek-style yogurt was used as a control (YC).
View Article and Find Full Text PDFColistin-resistant Escherichia coli mediated by the mcr-1 gene from pigs in northeastern Argentina.
Rev Argent Microbiol
February 2025
Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Junín 954, CP: C1113, Ciudad Autónoma de Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Godoy Cruz 2290 CP: C1425FQB, Ciudad Autónoma de Buenos Aires, Argentina.
The emergence and spread of multidrug-resistant Escherichia coli carrying mcr-1 is recognized as a threat to public health. The aim of this study was to determine the prevalence of the mcr-1 gene in colistin-resistant E. coli isolates from commercial pig farms in Chaco, Argentina from 2020 to 2021.
View Article and Find Full Text PDFPersistence to growth hormone treatment and clinical characteristics of pediatric patients with growth hormone deficiency: A retrospective cohort study of data from the Japan Medical Data Center claims database.
Endocr J
February 2025
Division of Pediatric Endocrinology, Metabolism and Nephrology, Children's Medical Center, Osaka City General Hospital, Osaka 534-0021, Japan.
Limited real-world data are available on persistence to growth hormone replacement therapy (GHRT) in Japan. Therefore, we used the Japan Medical Data Center claims database to retrospectively investigate persistence with GHRT in patients with pediatric growth hormone deficiency (pGHD). We identified 1,020 patients with pGHD treated with GHRT.
View Article and Find Full Text PDFBrightening of Optical Forbidden Interlayer Quantum Emitters in WSe Homobilayers.
ACS Nano
March 2025
Department of Physics, Stevens Institute of Technology, Hoboken, New Jersey 07030, United States.
Interlayer excitons (IXs) in layered van der Waals materials are promising for quantum technologies and fundamental studies such as exciton-polariton condensation due to their large permanent dipole moments. However, their indirect bandgap optical transition through the Q-K channel renders them momentum forbidden and thus less relevant for optical applications. Here, we demonstrate a method for brightening momentum indirect Q-K transitions from IX quantum emitters (QEs) in 2H-stacked bilayer WSe by simultaneously employing local strain and plasmonic nanocavity coupling.
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