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Myeloid cell heterogeneity in the tumor microenvironment and therapeutic implications for childhood central nervous system (CNS) tumors. | LitMetric

Myeloid cell heterogeneity in the tumor microenvironment and therapeutic implications for childhood central nervous system (CNS) tumors.

J Neuroimmunol

Nationwide Children's Hospital, Columbus, OH, United States of America; Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, United States of America. Electronic address:

Published: January 2023

AI Article Synopsis

  • Central nervous system (CNS) tumors are the most prevalent solid tumors in children and the leading cause of cancer deaths in those aged 0-14.
  • The review highlights recent research on the differences among various pediatric CNS tumor types, especially focusing on myeloid cells within the tumor microenvironment.
  • It also discusses the importance of recent studies on human CNS tumors and animal models, using advanced tools to understand how myeloid cell infiltration affects tumor development and response to treatment in young patients.

Article Abstract

Central nervous system (CNS) tumors are the most common type of solid tumors in children and the leading cause of cancer deaths in ages 0-14. Recent advances in the field of tumor biology and immunology have underscored the disparate nature of these distinct CNS tumor types. In this review, we briefly introduce pediatric CNS tumors and discuss various components of the TME, with a particular focus on myeloid cells. Although most studies regarding myeloid cells have been done on adult CNS tumors and animal models, we discuss the role of myeloid cell heterogeneity in pediatric CNS tumors and describe how these cells may contribute to tumorigenesis and treatment response. In addition, we present studies within the last 5 years that highlight human CNS tumors, the utility of various murine CNS tumor models, and the latest multi-dimensional tools that can be leveraged to investigate myeloid cell infiltration in young adults and children diagnosed with select CNS tumors.

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Source
http://dx.doi.org/10.1016/j.jneuroim.2022.578009DOI Listing

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