This noninvasive alternative to the diagnostic gold standard may cut risk and expense for adult patients.
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| http://dx.doi.org/10.12788/jfp.0485 | DOI Listing |
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Patient perceptions of the Finnish guidelines enabling coeliac disease diagnosis without biopsies in adults.
Scand J Gastroenterol
December 2024
Celiac Disease Research Centre, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Objectives: Diagnosis of coeliac disease based on serology only has been allowed since 2018 in Finland for adults meeting specific criteria. We studied the patient experiences and perceptions of this novel diagnostic option.
Methods: Altogether 194 adult patients were questioned on socio-demographic and health-related characteristics, quality of life and various coeliac disease-related issues.
Children with celiac disease, diagnosed with or without biopsy, present similar adherence to gluten-free diet and serology decline.
Eur J Pediatr
November 2024
Institute of Gastroenterology, Nutrition and Liver Diseases, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
Unlabelled: Current professional guidelines enable diagnosing pediatric Celiac Disease (CeD) without a biopsy, when tissue transglutaminase (TTG) IgA antibodies are > × 10 the upper limit of normal (ULN) and anti-endomysial antibodies (EMA) are positive in a second sample. We compared baseline characteristics and serology normalization in children diagnosed with or without biopsies. A retrospective study of pediatric patients diagnosed with CeD during 2020: group A, no biopsy and group B, biopsy-based diagnosis.
View Article and Find Full Text PDFCoeliac Disease in Children-A Clinical Review Including Novel Treatment Agents.
Medicina (Kaunas)
October 2024
Department of Gastroenterology, Perth Children's Hospital, Perth, WA 6009, Australia.
Coeliac disease (CD) affects almost of 1% of the population, yet remains undiagnosed in the majority. Though the demonstration of enteropathy in duodenal biopsy was traditionally the essential criterion for the diagnosis of coeliac disease, the guidelines published by the European Society of Paediatric Gastroenterology and Nutrition (ESPGHAN) in 2012, and revised in 2020, paved the way to a no-biopsy approach to diagnosis. In a select group of children meeting certain criteria, a definitive diagnosis of CD can now be made without the need for duodenal biopsies.
View Article and Find Full Text PDFEndomysial antibodies or anti-tissue transglutaminase type 2 IgA antibodies as a confirmatory test in children with celiac disease.
J Pediatr Gastroenterol Nutr
January 2025
Tel-Aviv Sourasky Medical Center, Dana-Dwek Children's Hospital, Pediatric Gastroenterology Institute, Tel Aviv, Israel.
The no-biopsy approach to diagnose celiac disease (CD), introduced in the 2012 European Society for Gastroenterology and Hepatology and Nutrition guidelines, requires an anti-endomysial antibody (EMA) confirmatory serology test following a high-positive immunoglobulin A anti-tissue transglutaminase-2 (anti-TG2) antibody ≥10 times the upper limit of normal (ULN). The aim of this retrospective study is to compare EMA positivity and high-positive anti-TG2 in patients who had their confirmatory test within 2 months of their first high-positive anti-TG2 test. Among 933 patients who had high-positive anti-TG2 serology more than 10 times the ULN in their first sample, all had both high-positive anti-TG2 and positive EMA, most of them with very high EMA titers (99.
View Article and Find Full Text PDFPatient preferences for the diagnosis of coeliac disease: A discrete choice experiment.
United European Gastroenterol J
August 2024
Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, UK.
Background: There is potential for a paradigm shift from a biopsy-to a serology-based diagnosis of coeliac disease in selected adult patients. However, it remains unknown if this approach would be acceptable to patients. We aimed to explore patients' preferences regarding the no-biopsy approach for coeliac disease diagnosis.
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