Catalytic enantioselective desymmetrization of -aziridines.

As a type of readily available small strained-ring heterocycle, -aziridines may undergo catalytic desymmetrizing transformations to empower the rapid construction of diverse nitrogen-containing structures bearing contiguous stereocenters, which have great relevance in natural product synthesis, drug development and the design and synthesis of chiral catalysts/ligands for asymmetric catalysis. This review outlines the advances achieved in the catalytic asymmetric desymmetrization of aziridines and highlights some promising avenues for further work in this realm.