Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/ana.410040418 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Fatal and Nonfatal Events Within 14 days After Early, Intensive Mobilization Poststroke.
Neurology
February 2021
From Stroke Theme, Florey Institute of Neuroscience and Mental Health (J.B., K.B., J.M.C., H.M.D., F.E., C.B.), and Department of Medicine Austin Health (L.C.), University of Melbourne, Heidelberg; NHMRC Centre for Research Excellence in Stroke Rehabilitation and Brain Recovery (J.B., K.B., L.C., G.A.D.); Stroke and Ageing Research, Department of Medicine, School of Clinical Sciences at Monash Health (A.G.T.), Eastern Health Clinical School, Faculty of Medicine, Nursing and Health Sciences (H.M.D.), CCRE Therapeutics (C.M.R.), Faculty of Medicine, Nursing and Health Sciences (J.H.F.), and Peninsula Health & Peninsula Clinical School (V.S.), Monash University, Melbourne, Australia; Institute of Cardiovascular and Medical Sciences (P.L.), University of Glasgow, UK; Nursing Research Institute (S.M.), St Vincent's Health Australia, Sydney and Australian Catholic University, Darlinghurst; Westmead Clinical School (R.I.L.), University of Sydney, Australia;Stroke Trials Unit, Division of Clinical Neuroscience (P.B.), University of Nottingham; Stroke, Nottingham University Hospitals NHS Trust (P.B.), Nottingham, UK; Physiotherapy (C.M.S.), University of Melbourne, Parkville; Physiotherapy (C.M.S.), Western Health, St Albans; School of Sciences (L.C.), RMIT University, Melbourne; Eastern Health Clinical School (C.B.), Monash University, Box Hill; School of Public Health (C.M.R.), Curtin University, Perth; Alfred Hospital (J.H.F.), Melbourne; Faculty of Medicine (S.J.R.), The University of Queensland, Herston; and University of Melbourne (G.A.D.), Melbourne Brain Centre, Parkville, Australia.
Objective: This tertiary analysis from A Very Early Rehabilitation Trial (AVERT) examined fatal and nonfatal serious adverse events (SAEs) at 14 days.
Method: AVERT was a prospective, parallel group, assessor blinded, randomized international clinical trial comparing mobility training commenced <24 hours poststroke, termed very early mobilization (VEM), to usual care (UC). Primary outcome was assessed at 3 months.
Edgar Douglas Adrian was an outstandingly brilliant, Nobel prize-winning neurophysiologist. He is remembered for developing the all-or-none principle of muscle contraction, and for explaining the minutiae of motor and sensory nerve transmission. He showed that the afferent effect in a neuron depends on the pattern in time of the impulses travelling in it, thereby providing a quantitative basis of nervous behaviour.
View Article and Find Full Text PDFRadiogenomics Monitoring in Breast Cancer Identifies Metabolism and Immune Checkpoints as Early Actionable Mechanisms of Resistance to Anti-angiogenic Treatment.
EBioMedicine
August 2016
Department of Oncology, University of Oxford, Oxford, UK. Electronic address:
Anti-VEGF antibody bevacizumab has prolonged progression-free survival in several cancer types, however acquired resistance is common. Adaption has been observed pre-clinically, but no human study has shown timing and genes involved, enabling formulation of new clinical paradigms. In a window-of-opportunity study in 35 ductal breast cancer patients for 2weeks prior to neoadjuvant chemotherapy, we monitored bevacizumab response by Dynamic Contrast-Enhanced Magnetic Resonance [DCE-MRI], transcriptomic and pathology.
View Article and Find Full Text PDFPrespecified dose-response analysis for A Very Early Rehabilitation Trial (AVERT).
Neurology
June 2016
From The Florey Institute of Neuroscience and Mental Health (J.B., L.C., F.E., J. Collier, J. Chamberlain, H.D., G.D.), La Trobe University (J.B.), Melbourne, Australia; Institute of Cardiovascular and Medical Sciences (P.L.), University of Glasgow, UK; George Institute for Global Health and Westmead Hospital Clinical School (R.I.L.), University of Sydney; Deakin Health Economics (M.M.), Faculty of Health, Deakin University, Burwood; and Eastern Health Clinical School, Faculty of Medicine, Nursing and Health Sciences (H.D.), and Stroke and Ageing Research Group, Department of Medicine, School of Clinical Sciences at Monash Health (A.G.T.), Monash University, Clayton, Australia.
Objective: Our prespecified dose-response analyses of A Very Early Rehabilitation Trial (AVERT) aim to provide practical guidance for clinicians on the timing, frequency, and amount of mobilization following acute stroke.
Methods: Eligible patients were aged ≥18 years, had confirmed first (or recurrent) stroke, and were admitted to a stroke unit within 24 hours of stroke onset. Patients were randomized to receive very early and frequent mobilization, commencing within 24 hours, or usual care.
AVERT2 (a very early rehabilitation trial, a very effective reproductive trigger): retrospective observational analysis of the number of babies born to trial staff.
BMJ
December 2015
University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK.
Objective: To report the number of participants needed to recruit per baby born to trial staff during AVERT, a large international trial on acute stroke, and to describe trial management consequences.
Design: Retrospective observational analysis.
Setting: 56 acute stroke hospitals in eight countries.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!