To explore the safety and efficacy of the integrated boost to the dominant intraprostatic nodule (DIN) based on Ga prostate-specific membrane antigen PET/MRI in stereotactic body radiation therapy (SBRT) for patients with localized prostate cancer. SBRT regimen is employed - namely, sequential integrated boost (SIB) to the DIN based on Ga prostate-specific membrane antigen PET/MRI. SIB prescription dose of 36.25 Gy in five fractions to fixed prophylactic tumoricidal region is delivered, followed by 7.25 Gy in one fraction added to the DIN every other day. The primary end point of the study will be toxicity assessed by the Common Terminology Criteria for Adverse Events 5.0 grading scale. Secondary end points include biochemical progression-free survival, local progression-free survival, distant metastasis-free survival and overall survival. This trial is to prove the safety and efficacy of sequential integrated boost to the DIN in SBRT. NCT04599699 (ClinicalTrials.gov).
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| http://dx.doi.org/10.2217/fon-2022-0590 | DOI Listing |
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