Federated Learning is a distributed machine learning framework that aims to train a global shared model while keeping their data locally, and previous researches have empirically proven the ideal performance of federated learning methods. However, recent researches found the challenge of statistical heterogeneity caused by the non-independent and identically distributed (non-IID), which leads to a significant decline in the performance of federated learning because of the model divergence caused by non-IID data. This statistical heterogeneity is dramatically restricts the application of federated learning and has become one of the critical challenges in federated learning. In this paper, a dynamic weighted model aggregation algorithm based on statistical heterogeneity for federated learning called DWFed is proposed, in which the index of statistical heterogeneity is firstly quantitatively defined through derivation. Then the index is used to calculate the weights of each local model for aggregating federated model, which is to constrain the model divergence caused by non-IID data. Multiple experiments on public benchmark data set reveal the improvements in performance and robustness of the federated models in heterogeneous settings.
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http://dx.doi.org/10.3389/fnbot.2022.1041553 | DOI Listing |
Life Med
June 2023
Collaborative Innovation Center for Brain Science, School of Life Science and Technology, Tongji University, Shanghai 200092, China.
China and the world are facing severe population aging and an increasing burden of age-related diseases. Aging of the brain causes major age-related brain diseases, such as neurodegenerative diseases and stroke. Identifying biomarkers for the effective assessment of brain aging and establishing a brain aging assessment system could facilitate the development of brain aging intervention strategies and the effective prevention and treatment of aging-related brain diseases.
View Article and Find Full Text PDFFront Optoelectron
January 2025
Institute of Physics, Saratov State University, Saratov, 410012, Russia.
The paper presents the results of modern research on the effects of electromagnetic terahertz radiation in the frequency range 0.5-100 THz at different levels of power density and exposure time on the viability of normal and cancer cells. As an accompanying tool for monitoring the effect of radiation on biological cells and tissues, spectroscopic research methods in the terahertz frequency range are described, and attention is focused on the possibility of using the spectra of interstitial water as a marker of pathological processes.
View Article and Find Full Text PDFNat Methods
January 2025
Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
Teravoxel-scale, cellular-resolution images of cleared rodent brains acquired with light-sheet fluorescence microscopy have transformed the way we study the brain. Realizing the potential of this technology requires computational pipelines that generalize across experimental protocols and map neuronal activity at the laminar and subpopulation-specific levels, beyond atlas-defined regions. Here, we present artficial intelligence-based cartography of ensembles (ACE), an end-to-end pipeline that employs three-dimensional deep learning segmentation models and advanced cluster-wise statistical algorithms, to enable unbiased mapping of local neuronal activity and connectivity.
View Article and Find Full Text PDFJ Biophotonics
January 2025
Britton Chance Center for Biomedical Photonics-MoE Key Laboratory for Biomedical Photonics, Huazhong University of Science and Technology, Wuhan, China.
Diabetes mellitus (DM), a chronic metabolic disorder that adversely affects the blood-brain barrier (BBB) and microglial function in the central nervous system (CNS), contributing to neuronal damage and neurodegenerative diseases. However, the underlying molecular mechanisms linking diabetes to BBB dysfunction and microglial dysregulation remain poorly understood. Here, we assessed the impacts of diabetes on BBB and microglial reactivity and investigated its mechanisms.
View Article and Find Full Text PDFNeurosci Lett
January 2025
Institute of Higher Nervous Activity and Neurophysiology, RAS, 5A Butlerova Street, 117485 Moscow, Russian Federation. Electronic address:
Contemporary analyses of neurophysiological mechanisms of associative learning suggest that instrumental behavior can be controlled by separable action and habit processes. An increasingly broad range of human psychiatric and neurological disorders are now associated with maladaptive habit formation. The question of how the brain controls transitions into habit is thus relevant.
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