and Investigation of Anti Activity of Selected Phytochemicals.

Introduction: is Gram-negative helical bacteria that inhibit stomach mucosal lining and establish infection. Urease enzyme was confirmed to be pivotal target in which its suppression will prompt bacteria treatment and eradication.

Methods: Series of naturally bioactive compounds were selected based on ethnobotanical and molecular modeling techniques with potential urease inhibitory effect. The selected phytochemical compounds were and assayed against urease enzyme, minimal inhibitory concentrations (MIC) and a synergistic effect was studied and cultured specifically for .

Results: Terpineol was considered as the most active compound with an IC of 1.443 μg/ml ( = 0.9374). The synergistic effect of terpineol and metronidazole indicated a possible additive effect (fractional inhibitory concentration result is 0.78) with improvement of MIC results for both terpineol and metronidazole.

Conclusion: This study suggests that terpineol is best to be considered as a lead compound for infection treatment and could be a potent inhibitor when combined with metronidazole targeting urease enzyme.