AI Article Synopsis
- Cartilage has limited self-repair abilities due to its lack of blood vessels and nerves, making issues like osteoarthritis hard to treat, with no effective cures available.
- Research focuses on various cell sources for creating articular cartilage, noting that autologous chondrocyte implantation has not shown strong long-term results.
- Mesenchymal stem cells (MSCs) appear to be the most promising option for cartilage regeneration, while human embryonic stem cells (hESCs) require more research to improve their differentiation into quality chondrocytes.
Article Abstract
As cartilage is an avascular, aneural structure, it has very low capabilities of self-repair. Osteoarthritis prevalence is increasing, and there are no clinically approved management techniques that can cure the degradation of cartilage. This report investigates the efficacy of different sources of cells to generate articular cartilage. Autologous chondrocyte implantation has been used to some extent in clinics; however it has not generated efficient, reliable results, and there is no evidence of long-term success. The usage of stem cells is more promising, particularly mesenchymal stem cells (MSCs). Human embryonic stem cells (hESCs) have also been trialed; however, it is important to note that the process of differentiation into chondrocytes is not fully understood, and the cartilage produced can often be of poor quality. MSCs seems to be the way forward, and hESCs will perhaps need further study with the usage of MSC differentiation methodology.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9727652 | PMC |
| http://dx.doi.org/10.7759/cureus.32280 | DOI Listing |
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