AI Article Synopsis
- Colorectal cancer (CRC) is a significant global health issue and a leading cause of cancer-related deaths, emphasizing the need for understanding its pathogenesis for better diagnosis and treatment.
- Intercellular adhesion molecule-1 (ICAM-1) is crucial in CRC development, affecting cell interactions, signaling, and immune responses, and is linked to tumor cell functions like invasion and metastasis.
- This review will explore the role of ICAM-1 in CRC, including its expression, functions, impacts on prognosis and tumor formation, genetic variations, and potential therapeutic targets.
Article Abstract
Colorectal cancer (CRC) is a major global health problem and one of the major causes of cancer-related death worldwide. It is very important to understand the pathogenesis of CRC for early diagnosis, prevention strategies and identification of new therapeutic targets. Intercellular adhesion molecule-1 (ICAM-1, CD54) displays an important role in the the pathogenesis of CRC. It is a cell surface glycoprotein of the immunoglobulin (Ig) superfamily and plays an essential role in cell-cell, cell-extracellular matrix interaction, cell signaling and immune process. It is also expressed by tumor cells and modulates their functions, including apoptosis, cell motility, invasion and angiogenesis. The interaction between ICAM-1 and its ligand may facilitate adhesion of tumor cells to the vascular endothelium and subsequently in the promotion of metastasis. ICAM-1 expression determines malignant potential of cancer. In this review, we will discuss the expression, function, prognosis, tumorigenesis, polymorphisms and therapeutic implications of ICAM-1 in CRC.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728583 | PMC |
| http://dx.doi.org/10.3389/fonc.2022.1052672 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
ICAM-1 K469E gene polymorphism, genotype-phenotype correlation, and retinopathy in Type 2 diabetes mellitus patients.
Ophthalmic Genet
January 2025
Department of Ophthalmology, PSG Institute of Medical Sciences and Research, Coimbatore, India.
Context: The role of genetic factors in the development of diabetic retinopathy is evident from the fact that only 50% of patients with the non-proliferative type of diabetic retinopathy progress to proliferative diabetic retinopathy. Though the K469E polymorphism of the ICAM-1 (Intercellular Adhesion Molecule-1) gene is known to increase the risk of developing Diabetic Retinopathy (DR) among Type 2 diabetic patients, its role in the development of severe DR has not been extensively studied.
Aim: Hence, we aimed to determine the risk due to association of K469E polymorphism of ICAM-1 gene and sight threatening diabetic retinopathy.
Exploring the Therapeutic Potentials and Molecular Mechanisms of Alkaloids in Ulcerative Colitis: An Integrative Network Pharmacology and Molecular Docking Approach.
Prev Nutr Food Sci
December 2024
School of Food Science & Biotechnology, Kyungpook National University, Daegu 41566, Korea.
, a medicinal plant traditionally used in Southeast Asia, exerts protective effects against various inflammatory diseases, primarily due to its rich alkaloid content. Despite substantial evidence supporting its anti-inflammatory properties, the biological activities of are unclear. This study aimed to elucidate anticolitis mechanisms of alkaloids (CFAs) using an integrative approach of network pharmacology and molecular docking analyses.
View Article and Find Full Text PDFAntithrombic effects of in a rat model of acute thrombosis: modulation of endothelial adhesion molecules and inflammatory factors.
Food Sci Biotechnol
January 2025
Department of Food Science and Biotechnology, Seoul National University of Science and Technology, 232, Gongneung-ro, Nowon-gu, Seoul, 01811 Republic of Korea.
(PR) is a tropical plant used as a spice in Southeast Asia. This study investigated the antithrombotic effect of PR in rats with acute thrombosis induced by collagen and epinephrine (CE). The rats were divided into four groups, control (CON), CE, PR15, and PR30, with PR administered at 15 and 30 mg/kg body weight.
View Article and Find Full Text PDFEarly circulating biomarkers to predict plasma leakage in dengue fever.
J Infect
January 2025
School of Biomedical Sciences, Faculty of Medicine, UNSW Sydney, NSW, 2052, Australia; Viral Immunology Systems Program, Kirby Institute, UNSW Sydney, NSW, 2052, Australia. Electronic address:
Article Synopsis
- Dengue is a significant health issue in low- and middle-income countries, with risks of severe outcomes like plasma leakage, making early patient identification crucial for effective hospital care.
- This study used a case-control approach to analyze plasma samples from dengue patients to identify potential biomarkers linked to plasma leakage within the first 96 hours of illness.
- Key findings showed that elevated levels of specific biomarkers (like Vascular cell adhesion molecule-1 and Interleukin 33 receptor) increased the risk of plasma leakage, while others (like eotaxin-1) were protective, highlighting their potential role in improving dengue patient care.
Host hepatocyte senescence determines the success of hepatocyte transplantation in a mouse model of liver injury.
J Hepatol
January 2025
Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, EH16 4UU, United Kingdom. Electronic address:
Background & Aims: Hepatocyte transplantation has shown promise for genetic diseases of the hepatocytes but to date has shown limited efficacy for non-genetic forms of severe liver injury. Limited cell engraftment and poor function of donor hepatocytes in recipient livers impacts the clinical utility of hepatocyte cell therapy. The mechanisms underpinning this are poorly understood.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!