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B cell fate mapping reveals their contribution to the memory immune response against helminths. | LitMetric

An estimated quarter of the human world population is infected with gastrointestinal helminths causing major socioeconomic problems in endemic countries. A better understanding of humoral immune responses against helminths is urgently needed to develop effective vaccination strategies. Here, we used a fate mapping (FM) approach to mark germinal center (GC) B cells and their developmental fates by induced expression of a fluorescent protein during infection of mice with the helminth . We could show that FM cells persist weeks after clearance of the primary infection mainly as CD80CD73PD-L2 memory B cells. A secondary infection elicited expansion of helminth-specific memory B cells and plasma cells (PCs). Adoptive transfers and analysis of somatic mutations in immunoglobulin genes further revealed that FM B cells rapidly convert to PCs rather than participating again in a GC reaction. These results provide new insights in the population dynamics of the humoral immune response against helminths.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730276PMC
http://dx.doi.org/10.3389/fimmu.2022.1016142DOI Listing

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