Introduction: Dementia as an inevitable aging consequence has been challenged and underscores the need for investigations of the factors that confer resilience. We examine whether the functionally advantageous KL-VS variant of the putative aging suppressor gene attenuates age-related cognitive decline and deleterious biomolecular changes.
Methods: Trajectories of change in memory and executive function ( = 360; 2-12 visits) and cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers-amyloid beta (Aβ)42, total tau (t-tau), phosphorylated tau (p-tau) ( = 112; 2-4 samplings)-were compared between KL-VS non-carriers and heterozygotes in middle-aged and older adults from the Wisconsin Registry for Alzheimer's Prevention and the Wisconsin Alzheimer's Disease Research Center studies.
Results: Memory and executive function declined ('s 0.001) and CSF t-tau, p-tau, t-tau/Aβ42, and p-tau/Aβ42 levels increased (all 's 0.004) with age. The rate of p-tau accumulation was attenuated for KL-VS heterozygotes ( 0.03).
Discussion: KL-VS heterozygosity may confer resilience to AD-associated biomolecular changes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728548 | PMC |
| http://dx.doi.org/10.1002/dad2.12383 | DOI Listing |
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