AI Article Synopsis
- The study compares fatal cases of COVID-19 and H7N9 in mainland China, focusing on clinical features and survival factors.
- It found similar demographic characteristics but differences in treatment effectiveness; H7N9 patients received more aggressive treatment than COVID-19 patients.
- Key protective factors for survival in COVID-19 included antibiotics, oxygen treatment, and corticosteroids, while antiviral drugs and corticosteroids were beneficial for H7N9 fatal cases, highlighting the need for ongoing pandemic surveillance.
Article Abstract
Objective: The outbreak of COVID-19 in 2020 is reminiscent of the H7N9 outbreak in 2013, which poses a huge threat to human health. We aim to compare clinical features and survival factors in fatal cases of COVID-19 and H7N9.
Methods: Data on confirmed COVID-19 and H7N9 fatal cases identified in mainland China were analyzed to compare demographic characteristics and clinical severity. Survival curves were estimated by the Kaplan-Meier method and compared using log-rank tests and a restricted mean survival time model. A Cox regression model was used to identify survival factors in fatal cases of COVID-19 and H7N9.
Results: Similar demographic characteristics were observed in fatal cases of COVID-19 and H7N9. The proportion of fatal cases of H7N9 receiving antibiotics, antiviral drugs, and oxygen treatment was higher than that of COVID-19. The potential protective factors for fatal COVID-19 cases were receiving antibiotics (HR: 0.37, 95% CI: 0.22-0.61), oxygen treatment (HR: 0.66, 95% CI: 0.44-0.99), and corticosteroids (HR: 0.46, 95% CI: 0.35-0.62). In contrast, antiviral drugs (HR: 0.21, 95% CI: 0.08-0.56) and corticosteroids (HR: 0.45, 95% CI: 0.29-0.69) were the protective factors for H7N9 fatal cases.
Conclusion: The proportion of males, those having one or more underlying medical condition, and older age was high in COVID-19 and H7N9 fatal cases. Offering antibiotics, oxygen treatment, and corticosteroids to COVID-19 cases extended the survival time. Continued global surveillance remains an essential component of pandemic preparedness.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9729836 | PMC |
| http://dx.doi.org/10.3389/fpubh.2022.1047362 | DOI Listing |
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