AI Article Synopsis
- [F]mFBG is a special type of imaging test that helps doctors see tumors in kids with a disease called neuroblastoma.
- In a study with 14 young patients, two different imaging methods ([I]mIBG and [F]mFBG) were compared to see which one found more tumors.
- The study showed that [F]mFBG found more tumors and was quicker to perform, making it a promising option for doctors to help in treating neuroblastoma.
Article Abstract
Purpose: Meta-[F]fluorobenzylguanidine ([F]mFBG) is a positron emission tomography (PET) radiotracer that allows for fast and high-resolution imaging of tumours expressing the norepinephrine transporter. This pilot study investigates the feasibility of [F]mFBG PET-CT for imaging in neuroblastoma.
Methods: In a prospective, single-centre study, we recruited children with neuroblastoma, referred for meta-[I]iodobenzylguanidine ([I]mIBG) scanning, consisting of total body planar scintigraphy in combination with single-photon emission computed tomography-CT (SPECT-CT). Within two weeks of [I]mIBG scanning, total body PET-CTs were performed at 1 h and 2 h after injection of [F]mFBG (2 MBq/kg). Detected tumour localisations on scan pairs were compared. Soft tissue disease was quantified by number of lesions and skeletal disease by SIOPEN score.
Results: Twenty paired [I]mIBG and [F]mFBG scans were performed in 14 patients (median age 4.9 years, n = 13 stage 4 disease and n = 1 stage 4S). [F]mFBG injection was well tolerated and no related adverse events occurred in any of the patients. Mean scan time for [F]mFBG PET-CT (9.0 min, SD 1.9) was significantly shorter than for [I]mIBG scanning (84.5 min, SD 10.5), p < 0.01. Most tumour localisations were detected on the 1 h versus 2 h post-injection [F]mFBG PET-CT. Compared to [I]mIBG scanning, [F]mFBG PET-CT detected a higher, equal, and lower number of soft tissue lesions in 40%, 55%, and 5% of scan pairs, respectively, and a higher, equal, and lower SIOPEN score in 55%, 30%, and 15% of scan pairs, respectively. On average, two more soft tissue lesions and a 6-point higher SIOPEN score were detected per patient on [F]mFBG PET-CT compared to [I]mIBG scanning.
Conclusion: Results of this study demonstrate feasibility of [F]mFBG PET-CT for neuroblastoma imaging. More neuroblastoma localisations were detected on [F]mFBG PET-CT compared to [I]mIBG scanning. [F]mFBG PET-CT shows promise for future staging and response assessment in neuroblastoma.
Trial Registration: Dutch Trial Register NL8152.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931849 | PMC |
| http://dx.doi.org/10.1007/s00259-022-06063-6 | DOI Listing |
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