AI Article Synopsis
- The PI3K/AKT/mTOR pathway plays a crucial role in cell functions like growth and survival, making it a target for treatments of various diseases, including cancers and diabetes.
- Numerous clinical studies advocate for the development of new drugs specifically aimed at this pathway.
- The review discusses advancements in different types of inhibitors and suggests strategies to tackle issues like drug resistance and toxicity in existing treatments.
Article Abstract
The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway is one of the most important intracellular pathways involved in cell proliferation, growth, differentiation, and survival. Therefore, this route is a prospective biological target for treating various human diseases, such as tumors, neurodegenerative diseases, pulmonary fibrosis, and diabetes. An increasing number of clinical studies emphasize the necessity of developing novel molecules targeting the PI3K/AKT/mTOR pathway. This review focuses on recent advances in ATP-competitive inhibitors, allosteric inhibitors, covalent inhibitors, and proteolysis-targeting chimeras against the PI3K/AKT/mTOR pathway, and highlights possible solutions for overcoming the toxicities and acquired drug resistance of currently available drugs. We also provide recommendations for the future design and development of promising drugs targeting this pathway.
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| http://dx.doi.org/10.1021/acs.jmedchem.2c01070 | DOI Listing |
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