AI Article Synopsis
- Oncolytic viruses, like WNV-poly(A), selectively replicate in cancer cells and enhance the immune response, making them promising for cancer therapy.
- WNV-poly(A) is a live attenuated vaccine that effectively targets multiple cancer types, kills tumor cells while sparing normal cells, and activates immune responses through dendritic cells and CD8+ T cells.
- Experiments show that WNV-poly(A) significantly delays tumor progression in various cancer models, highlighting its potential as a new and effective treatment option for metastatic and recurrent tumors.
Article Abstract
As an emerging tumor therapy, ideal oncolytic viruses preferentially replicate in malignant cells, reverse the immunosuppressive tumor microenvironment, and eventually can be eliminated by the patient. It is of great significance for cancer treatment to discover new excellent oncolytic viruses. Here, we found that WNV live attenuated vaccine WNV-poly(A) could be developed as a novel ideal oncolytic agent against several types of cancers. Mechanistically, due to its high sensitivity to type Ι interferon (IFN-Ι), WNV-poly(A) could specifically kill tumor cells rather than normal cells. At the same time, WNV-poly(A) could activate Dendritic cells (DCs) and trigger tumor antigen specific response mediated by CD8 + T cell, which contributed to inhibit the propagation of original and distal tumor cells. Like intratumoral injection, intravenous injection with WNV-poly(A) also markedly delays Huh7 hepatic carcinoma (HCC) transplanted tumor progression. Most importantly, in addition to an array of mouse xenograft tumor models, WNV-poly(A) also has a significant inhibitory effect on many different types of patient-derived tumor tissues and HCC patient-derived xenograft (PDX) tumor models. Our studies reveal that WNV-poly(A) is a potent and excellent oncolytic agent against many types of tumors and may have a role in metastatic and recurrent tumors.
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| http://dx.doi.org/10.1016/j.biopha.2022.114094 | DOI Listing |
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