AI Article Synopsis
- Recent studies show corticosteroids can reduce wound fluid after surgeries but might also impair healing due to their immune effects.
- The study aimed to investigate the effects of the corticosteroid triamcinolone on cell migration in patients undergoing abdominoplasty.
- Results indicated no significant difference in cell migration between fibroblasts treated with triamcinolone and those without, suggesting triamcinolone does not hinder the process considered essential for wound healing.
Article Abstract
Background: Recent studies have demonstrated that local application of corticosteroids reduces wound exudation following abdominoplasty and other reconstructive surgical procedures. On the other hand, corticosteroids might provoke wound healing disturbances due to their immunosuppressive effects.
Objective: The main objective of this study was to gain further information about the impact of the corticosteroid triamcinolone on cell migration in abdominoplasty patients.
Methods: An in-vitro scratch assay wound healing model was applied to observe cell migration of fibroblasts cultured with nutrient medium containing human seroma aspirate±triamcinolone.
Results: There were no significant differences regarding cell migration when fibroblasts were incubated with triamcinolone + seroma containing culture medium compared to seroma containing culture medium without triamcinolone.
Conclusions: The performed in-vitro study suggests that triamcinolone does not decelerate fibroblast cell migration which is considered as a surrogate of wound healing.
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| http://dx.doi.org/10.3233/CH-229106 | DOI Listing |
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