Motion planning is one of the important research topics of robotics. As an improvement of Rapidly exploring Random Tree (RRT), the RRT* motion planning algorithm is widely used because of its asymptotic optimality. However, the running time of RRT* increases rapidly with the number of potential path vertices, resulting in slow convergence or even an inability to converge, which seriously reduces the performance and practical value of RRT*. To solve this issue, this paper proposes a two-phase motion planning algorithm named Metropolis RRT* (M-RRT*) based on the Metropolis acceptance criterion. First, to efficiently obtain the initial path and start the optimal path search phase earlier, an asymptotic vertex acceptance criterion is defined in the initial path estimation phase of M-RRT*. Second, to improve the convergence rate of the algorithm, a nonlinear dynamic vertex acceptance criterion is defined in the optimal path search phase, which preferentially accepts vertices that may improve the current path. The effectiveness of M-RRT* is verified by comparing it with existing algorithms through the simulation results in three test environments.
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http://dx.doi.org/10.3390/s22239203 | DOI Listing |
J Clin Pharmacol
January 2025
Center for Research and Innovation in Clinical Pharmaceutical Sciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Amoxicillin is commonly used to treat erythema migrans in the first stage of Lyme disease in children, with a recommended dose of 50 mg/kg/day, administered three times a day (q8h). This model-based simulation study aimed to determine whether splitting the same daily dose into two administrations (q12h) would provide comparable drug exposure. A pharmacokinetic model suitable for a pediatric population (age: 1 month to 18 years, weight: 4-80 kg) was selected through a literature review.
View Article and Find Full Text PDFScand J Clin Lab Invest
January 2025
Department of Medical Biochemistry, Health Science University, Istanbul Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey.
This study assessed the reliability of Roche Accu-Chek Inform II glucometers in a real-world setting. A retrospective analysis was conducted on 6,695 paired results. Capillary samples were tested using Roche Accu-Chek Inform II glucometers, while venous samples were analyzed using Roche Cobas c503/702 analyzers.
View Article and Find Full Text PDFPLoS One
January 2025
INSERM U1151, Université Paris Cité, Centre de Références Maladies Rares Mucoviscidose et Maladies Apparentées, Hôpital Necker Enfants Malades, Paris, France.
The Cystic Fibrosis (CF) Impact Questionnaire (CF-IQ) was qualitatively developed to assess the impact of CF in the context of treatment advancements and increased longevity. This study reports the CF-IQ validation. In this noninterventional validation study, people with CF completed the 40-item CF-IQ and validating patient-reported outcome measures (PROMs) via electronic diaries at enrollment (baseline) and at the 4-week follow-up.
View Article and Find Full Text PDFOral Maxillofac Surg
January 2025
North Cumbria University Hospitals NHS Trust, Carlisle, UK.
Introduction: Increasing emphasis has been placed on measurement of quality of life (QOL) as a central criterion for assessment of success of any medical treatment. The aim of our study was to assess the nutritional and quality of life of patient-reported outcomes among patients who have undergone laser resection of tongue cancer.
Materials And Methods: A cross-sectional study was undertaken of patients treated with KTP laser resection of T1/T2 tongue squamous cell carcinoma (SCC) between 2011-2019.
DEN Open
April 2025
Department of Surgery Rajavithi Hospital College of Medicine Rangsit University Bangkok Thailand.
Objectives: Choledocholithiasis is the leading cause of biliary pancreatitis and biliary sepsis. Endoscopic retrograde cholangiopancreatography (ERCP) is considered a minimally invasive treatment for choledocholithiasis. However, diagnostic ERCP should be avoided.
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