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Effect of Two Different Dietary Weight Loss Strategies on Risk Factors for Urinary Stone Formation and Cardiometabolic Risk Profile in Overweight Women. | LitMetric

AI Article Synopsis

  • Overweight individuals may have a higher risk of developing kidney stones, prompting research on weight loss diets to understand their effects on stone formation.
  • A study compared two weight loss diets—one including meal replacements and the other conventional meals—on risk factors for kidney stones among overweight women without a prior history of stones.
  • Results showed that the meal replacement group experienced greater weight loss and overall improvement in cardiometabolic health, including better reductions in uric acid levels compared to the conventional diet group.

Article Abstract

Overweight has been suggested to increase the risk of kidney stone formation. Although weight reduction might affect risk factors for urolithiasis, findings on the impact of different dietary weight loss strategies are limited. This randomized, controlled study evaluated the effect of a conventional energy-restricted modified diet with (MR group) or without meal replacement (C group) on risk factors for stone formation in overweight women without a history of urolithiasis. Of 105 participants, 78 were included into the per-protocol analysis. Anthropometric, clinical, biochemical, and 24 h urinary parameters were collected at baseline and after 12 weeks. Although both dietary interventions resulted in a significant weight reduction, relative weight loss and rate of responders were higher in the MR group. Weight loss improved cardiometabolic risk profile in both groups. Unfortunately, the benefit of decreased GPT activity in the C group was offset by a significant increase in homocysteine and a decline in GFR. While the relative supersaturation of calcium oxalate decreased significantly in both groups, a significant decline in serum uric acid concentration and relative supersaturation of uric acid was observed only in the MR group. Finally, the energy-restricted modified diet with meal replacement showed significant advantages over the energy-restricted modified diet alone.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736858PMC
http://dx.doi.org/10.3390/nu14235054DOI Listing

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